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Series GSE11413 Query DataSets for GSE11413
Status Public on May 01, 2009
Title Me-DIP-chip data from osteosarcoma cell lines
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Malignant cells show major disruptions in DNA methylation profiles which manifest as aberrant hypermethylation and hypomethylation of gene promoters as well as global genomic hypomethylation. To date, many genes with aberrant promoter hypermethylation have been identified in essentially all forms of cancer including cell cycle regulators, DNA repair genes, genes associated with apoptosis, hormonal regulation, detoxification, metastasis, angiogenesis, and many others
We developed an effective high-resolution approach for mapping genome-wide, and cancer-specific DNA methylation profiles. We have used this approach to provide first genomic DNA methylation profiling in osteosarcoma cells
Keywords: comparative profiling
 
Overall design We utilized this platform in combination with the methylated DNA immunoprecipitation (Me-DIP) to develop a comprehensive approach for detection of hypo- and hypermethylation changes at high resolution, and used it to detect such changes in human osteosarcoma cells in relation to the normal human osteoblasts.
 
Contributor(s) Sadikovic B
Citation(s) 18698372
Submission date May 12, 2008
Last update date Jan 21, 2015
Contact name Bekim Sadikovic
E-mail(s) bsadikov@gmail.com
Organization name The SickKids Hospital and Princess Margaret Hospital
Street address 555 University Avenue
City Toronto
State/province Ontario
ZIP/Postal code M5G 1X8
Country Canada
 
Platforms (1)
GPL5082 [Hs_PromPR] Affymetrix Human Promoter 1.0R Array
Samples (12)
GSM287993 U2OS IP1
GSM287994 U2OS IP2
GSM287995 U2OS IN1
This SubSeries is part of SuperSeries:
GSE11416 Comparison of osteosarcoma cell lines and normal human osteoblasts
Relations
BioProject PRJNA109227

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE11413_PGS_analysis.txt 514.0 Kb (ftp)(http) TXT
GSE11413_RAW.tar 237.5 Mb (http)(custom) TAR (of CEL)
GSE11413_README.txt 2.8 Kb (ftp)(http) TXT
Processed data are available on Series record

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