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| Status |
Public on Apr 08, 2019 |
| Title |
A network of transcriptome modules demonstrates mechanistic pathways of both virus induced and non-viral asthma exacerbations in children [nasal] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We leverage a systems-scale network analysis approach to demonstrate repertoires of cellular transcriptional pathways underlying loss of asthma control, and show how these pathways differ in viral associated and non-viral exacerbations.
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| Overall design |
208 children with exacerbation prone asthma were enrolled according to the inclusion criteria. Each child had baseline samples collected and were prospectively monitored for the onset of cold symptoms (Events) during a 6 month period. 106/208 children came in during one or more events and had sufficient samples collected for analysis. Events were grouped as exacerbation associated (Ex+) or not exacerbation associated (Ex-) depending on whether the event lead to clinical symptoms that resulted in systemic corticosteroid use within 10 days of event onset or resolved without treatment with systemic corticosteroids. The primary endpoint compared Ex+ events to Ex- events. Based on nasal virus PCR results, events were further classified as virus associated (V+) or nonviral (V-). The secondary endpoint compared V+Ex+, V+Ex-, V-Ex+, and V-Ex- events.
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| Contributor(s) |
Altman MC, Gill MA, Whalen E, Babineau D, Shao B, Liu AH, Jepson B, Gruchalla RS, O'Connor GT, Pongracic JA, Kercsmar CM, Khurana Hershey GK, Zoratti EM, Teach SJ, Kattan M, Bacharier LB, Beigelman A, Sigelman SM, Presnell SR, Gern JE, Gergen PJ, Wheatley L, Togias A, Busse WW, Jackson DJ |
| Citation(s) |
30962590 |
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| Submission date |
Jun 13, 2018 |
| Last update date |
Jan 03, 2024 |
| Contact name |
Stephanie Osmond |
| E-mail(s) |
sosmond@benaroyaresearch.org
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| Organization name |
Benaroya Research Institute
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| Street address |
1201 9th Ave
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| City |
Seattle, |
| State/province |
WA |
| ZIP/Postal code |
98101 |
| Country |
USA |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (523)
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| This SubSeries is part of SuperSeries: |
| GSE115824 |
A network of transcriptome modules demonstrates mechanistic pathways of both virus induced and non-viral asthma exacerbations in children |
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| Relations |
| BioProject |
PRJNA475981 |
| SRA |
SRP150456 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE115770_raw_counts_nasal_muppits523.txt.gz |
13.7 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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