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Series GSE116382 Query DataSets for GSE116382
Status Public on Jun 28, 2021
Title Transcriptome analysis of WWC2-deficient E11.5 embryos
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The Hippo signaling pathway is known to regulate cell differentiation, proliferation and apoptosis. The WWC proteins, WWC1 and WWC2, positively regulate the Hippo pathway by the activation of the LATS kinases and the subsequent cytoplasmic translocation of YAP. The in vivo role of WWC2 has not been studied, yet. We could show, that the ubiquitous knockout of WWC2 in mice leads to placental defects, growth retardation, a disturbed angiogenesis and vascularization resulting in embryonic lethality at around E11.5. To further understand the function of WWC2 in the embryonic development, a transcriptome analysis by next generation sequencing was performed.
Overall design The gene expression of 4 samples of E11.5 embryos homozygous for the WWC2 deletion were compared to 3 samples of E11.5 embryos heterozygous for the WWC2 deletion and 3 samples of wildtype embryos
Contributor(s) Hermann A, Kremerskothen J
Citation(s) 33483469
Submission date Jun 28, 2018
Last update date Nov 05, 2021
Contact name Anke Hermann
Organization name University Hospital Münster
Department Internal Medicine D
Lab Molecular Nephrology
Street address Albert-Schweitzer-Campus 1
City Münster
ZIP/Postal code 48149
Country Germany
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (10)
GSM3230370 WT rep1
GSM3230371 WT rep2
GSM3230372 WT rep3
BioProject PRJNA478336
SRA SRP151543

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Supplementary file Size Download File type/resource
GSE116382_genes_wt_vs_hetero.txt.gz 1.4 Mb (ftp)(http) TXT
GSE116382_genes_wt_vs_homo.txt.gz 1.2 Mb (ftp)(http) TXT
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Processed data are available on Series record

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