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Series GSE11723 Query DataSets for GSE11723
Status Public on Jun 02, 2009
Title Role of Notch signaling on hematopoietic stem cell differentiation
Organism Mus musculus
Experiment type Expression profiling by array
Summary Although Notch signaling has been clearly implicated in lymphoid differentiation, its role in myeloid lineages differentiation is unclear.
Expression data from hematopoietic stem cells plated on OP9 stroma expressing or not the Notch ligand Delta-like1. Results provide insight into the role of Notch signalling in megakaryocyte fate specification.

Keywords: Gene expression array-based (RNA / in situ oligonucleotide)
Overall design LSK cells were co-cultured for 3 days on OP9, OP9-DL1 and OP9-DL1+CompoundE (gamma-secretase inhibitor) and expression analysis was performed.
Contributor(s) Mercher T, Gilliland GD
Citation(s) 18786418
Submission date Jun 09, 2008
Last update date Feb 11, 2019
Contact name Thomas Mercher
Organization name Harvard Medical School
Department Hematology
Lab Dr. Gary Gilliland
Street address 1 blackfan circle
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (9)
GSM297554 LSK_OP9-GFP_Rep1
GSM297555 LSK_OP9-GFP_Rep2
GSM297556 LSK_OP9-GFP_Rep3
BioProject PRJNA106021

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE11723_RAW.tar 31.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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