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Series GSE118859 Query DataSets for GSE118859
Status Public on Sep 02, 2019
Title SOX2 epidermal overexpression promotes cutaneous wound healing via activation of EGFR/MEK/ERK signaling mediated by EGFR ligands
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We perfomed RNA-seq and wound healing analysis to identify the mechanism how SOX2 promote wound healing. We showed that induction of SOX2 in skin keratinocytes accelerates cutaneous wound healing by promoting keratinocyte migration and proliferation, and enhancement of angiogenesis via the upregulation of EGFR ligands.
Overall design Whole skin mRNA profiles in the unwounded (Day0) or wounded (Day4) state from Vehicle or Tamoxifen treated mice were examined in triplicate or quadruplicate.
Contributor(s) Morasso MI, Brooks SR, Uchiyama A
Citation(s) 30772301
Submission date Aug 21, 2018
Last update date Dec 03, 2019
Contact name Maria Irene Morasso
Phone 3014357842
Organization name NIAMS NIH
Lab Laboratory of Skin Biology
Street address Bldg 50
City Bethesda
State/province Maryland
ZIP/Postal code 20892
Country USA
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (15)
GSM3349393 Tam_unwounded_2 [s01]
GSM3349394 Tam_unwounded_3 [s03]
GSM3349395 Tam_unwounded_4 [s05]
BioProject PRJNA487061
SRA SRP158518

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE118859_170919_0085_rna-seq_results.gene.ANOVA.xlsx 5.2 Mb (ftp)(http) XLSX
GSE118859_170919_0085_rna-seq_results.gene.rpkm.xlsx 3.9 Mb (ftp)(http) XLSX
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Processed data are available on Series record

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