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Series GSE119369 Query DataSets for GSE119369
Status Public on Feb 20, 2020
Title Inhibition of cancer cell self-renewal through an epigenetic HDACi-histone H1.0 axis.
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Identification of HDACi-responsive, H1.0-dependent genes inhibiting self-renewal of HCC1569 breast cancer cells.
 
Overall design RNA-seq analysis of HCC1569 breast cancer cells containing an inducible H1.0-targeting shRNA, treated with HDACi (JNJ-26481585). RNA was collected at various time points after addition of HDACi (or DMSO as a control). Two conditions were compared: cells treated with doxycycline to induce expression of the shRNA (DOX), and uninduced cells (NT).
 
Contributor(s) Morales Torres C, Patel H, Scaffidi P
Citation(s) 32286289
Submission date Sep 03, 2018
Last update date Apr 22, 2020
Contact name Paola Scaffidi
E-mail(s) paola.scaffidi@crick.ac.uk
Organization name Francis Crick Institute
Lab Cancer Epigenetics Laboratory
Street address 1 Midland Road
City London
ZIP/Postal code NW1 1AT
Country United Kingdom
 
Platforms (1)
GPL20301 Illumina HiSeq 4000 (Homo sapiens)
Samples (30)
GSM3373838 HCC1569 DMSO NT biological replicate 1
GSM3373839 HCC1569 DMSO NT biological replicate 2
GSM3373840 HCC1569 DMSO NT biological replicate 3
Relations
BioProject PRJNA488996
SRA SRP159451

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE119369_allSamples_RNASeq_RSEM_TPM.tsv.gz 1.2 Mb (ftp)(http) TSV
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Raw data are available in SRA
Processed data are available on Series record

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