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Series GSE120161 Query DataSets for GSE120161
Status Public on Jan 25, 2019
Title Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary How neuronal connections are established and organized in functional networks determines brain function. In the mouse cerebral cortex, different classes of GABAergic interneurons exhibit specific connectivity patterns that underlie their ability to shape temporal dynamics and information processing. Much progress has been made parsing interneuron diversity, yet the molecular mechanisms by which interneuron subtype-specific connectivity motifs emerge remain unclear. Here we investigate transcriptional dynamics in different classes of interneurons during the formation of cortical inhibitory circuits. We found that whether the interneurons synapse with pyramidal neurons on their dendrites, soma, or axon initial segment is determined by synaptic molecules that are expressed in a subtype-specific manner. Thus cell-specific molecular programs that unfold during early postnatal development underlie the connectivity patterns of cortical interneurons.
Overall design RNAseq of three different subtypes of GABAergic inhibitory neurons (SST+, PV+ and Chandelier cells) at two developmental stages (P5 and P10) from mouse cortical regions as well as three control populations: interneurons at P0, pyramidal excitatory neurons at P12 and PLP+ oligodendrocytes at P10.
Contributor(s) Favuzzi E, Deogracias R, Maeso P, Rico B
Citation(s) 30679375, 35977514
Submission date Sep 18, 2018
Last update date Aug 31, 2022
Contact name Emilia Favuzzi
Organization name Harvard Medical School
Department Neurobiology
Lab Fishell lab
Street address 220 Longwood Avenue, Armenise 217
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (29)
GSM3395022 SS10_4936_TTGT [ss10_rep1]
GSM3395023 MP10_5982_ACGT [ss10_rep2]
GSM3395024 M10c_7156_ATAT [ss10_rep3]
BioProject PRJNA491753
SRA SRP162076

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MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE120161_ch10-inp0.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ch10-plp.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ch10-pv10.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ch10-pv5.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ch10-pyr.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ch10-ss10.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ch10-ss5.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ch8-ch10.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ch8-inp0.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ch8-plp.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ch8-pv10.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ch8-pv5.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ch8-pyr.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ch8-ss10.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ch8-ss5.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_fpkm_replicates.xlsx 7.4 Mb (ftp)(http) XLSX
GSE120161_inp0-plp.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_inp0-pyr.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_pv10-inp0.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_pv10-plp.diff.gz 1.2 Mb (ftp)(http) DIFF
GSE120161_pv10-pv5.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_pv10-pyr.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_pv10-ss10.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_pv10-ss5.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_pv5-inp0.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_pv5-plp.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_pv5-pyr.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_pv5-ss10.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_pv5-ss5.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_pyr-plp.diff.gz 1.2 Mb (ftp)(http) DIFF
GSE120161_ss10-inp0.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ss10-plp.diff.gz 1.2 Mb (ftp)(http) DIFF
GSE120161_ss10-pyr.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ss5-inp0.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ss5-plp.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ss5-pyr.diff.gz 1.3 Mb (ftp)(http) DIFF
GSE120161_ss5-ss10.diff.gz 1.3 Mb (ftp)(http) DIFF
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