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| Status |
Public on Nov 21, 2008 |
| Title |
Effect of Sirolimus treatment on lupus nephritis in NZB/W F1 female mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
NZB/WF1 female mice spontaneously develop autoimmune lupus nephritis. Expression profiling of kidney tissue from (a) 12 week NZB/W F1 female mice defined as asymptomatic for lupus nephritis, (b) 36 and 42 week NZB/W F1 female mice defined as diseased/symptomatic for lupus nephritis and (c) 36 and 42 week NZB/W F1 female mice that are diseased/symptomatic for lupus nephritis and treated with Sirolimus was carried out. The goal of the study was to identify genes associated with lupus nephritis and modulated by Sirolimus, an inhibitor of mTOR. In addition, lupus nephritis genes resistant to Sirolimus therapy were also identfied
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| Overall design |
This series of samples comprises of kidney tissue from (a) 12 week old NZB/W F1 female mice defined as asymptomatic for lupus nephritis (N=4), (b) 36 (N=3) and 42 week (N=3) old NZB/W F1 female mice defined as diseased/symptomatic for lupus nephritis and (c) 36 (N=3)and 42 (N=3) week old NZB/W F1 female mice that are asymptomatic for lupus nephritis on treatment with Sirolimus
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| Contributor(s) |
Legault HM, Reddy PS, Sypek JP, Collins MJ, Goad E, Goldman SJ, Liu W, Murray S, Dorner AJ, O'Toole M |
| Citation(s) |
18980674 |
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| Submission date |
Jul 07, 2008 |
| Last update date |
Jul 08, 2016 |
| Contact name |
Padmalatha Reddy |
| E-mail(s) |
preddy@wyeth.com
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| Organization name |
WYETH
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| Street address |
35 Cambridgepark Drive
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| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02140 |
| Country |
USA |
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| Platforms (2) |
| GPL75 |
[Mu11KsubA] Affymetrix Murine 11K SubA Array |
| GPL76 |
[Mu11KsubB] Affymetrix Murine 11K SubB Array |
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| Samples (32)
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| GSM303961 |
SLE-7 #1 @36wks, asymptomatic on treatment with sirolimus (-2101366109) |
| GSM303962 |
SLE-7 #3 @42wks, asymptomatic on treatment with sirolimus (-2101365164) |
| GSM303963 |
SLE-7 #1 @12wks, asymptomatic (-2069738435) |
| GSM303964 |
SLE-7 #2 @42wks, diseased/symptomatic (-2101152267) |
| GSM303965 |
SLE-7 #2 @42wks, diseased/symptomatic (-2102085823) |
| GSM303966 |
SLE-7 #4 @12wks, asymptomatic (-2077090517) |
| GSM303967 |
SLE-7 #2 @42wks, asymptomatic on treatment with sirolimus (-2101152249) |
| GSM303968 |
SLE-7 #1 @42wks, diseased/symptomatic (-2101365185) |
| GSM303969 |
SLE-7 #3 @36wks, asymptomatic on treatment with sirolimus (-2101152279) |
| GSM303970 |
SLE-7 #1 @36wks, asymptomatic on treatment with sirolimus (-2099597727) |
| GSM303971 |
SLE-7 #2 @36wks, diseased/symptomatic (-2101366115) |
| GSM303972 |
SLE-7 #3 @12wks, asymptomatic (-2077090523) |
| GSM303973 |
SLE-7 #1 @36wks, diseased/symptomatic (-2101366147) |
| GSM303974 |
SLE-7 #3 @42wks, diseased/symptomatic (-2099597707) |
| GSM303975 |
SLE-7 #3 @36wks, diseased/symptomatic (-2101152297) |
| GSM303976 |
SLE-7 #3 @42wks, asymptomatic on treatment with sirolimus (-2101152243) |
| GSM303977 |
SLE-7 #2 @36wks, diseased/symptomatic (-2101152303) |
| GSM303978 |
SLE-7 #2 @42wks, asymptomatic on treatment with sirolimus (-2102085846) |
| GSM303979 |
SLE-7 #3 @36wks, asymptomatic on treatment with sirolimus (-2101365196) |
| GSM303980 |
SLE-7 #3 @36wks, diseased/symptomatic (-2102085829) |
| GSM303981 |
SLE-7 #3 @42wks, diseased/symptomatic (-2101365176) |
| GSM303982 |
SLE-7 #1 @42wks, asymptomatic on treatment with sirolimus (-2101365170) |
| GSM303983 |
SLE-7 #2 @36wks, asymptomatic on treatment with sirolimus (-2099597721) |
| GSM303984 |
SLE-7 #3 @12wks, asymptomatic (-2069737912) |
| GSM303985 |
SLE-7 #2 @36wks, asymptomatic on treatment with sirolimus (-2101365652) |
| GSM303986 |
SLE-7 #2 @12wks, asymptomatic (-2077090529) |
| GSM303987 |
SLE-7 #1 @42wks, diseased/symptomatic (-2101152273) |
| GSM303988 |
SLE-7 #2 @12wks, asymptomatic (-2069738429) |
| GSM303989 |
SLE-7 #1 @42wks, asymptomatic on treatment with sirolimus (-2099597697) |
| GSM303990 |
SLE-7 #4 @12wks, asymptomatic (-2069619621) |
| GSM303991 |
SLE-7 #1 @12wks, asymptomatic (-2077090535) |
| GSM303992 |
SLE-7 #1 @36wks, diseased/symptomatic (-2101152309) |
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| Relations |
| BioProject |
PRJNA113299 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE12024_RAW.tar |
69.0 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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