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Series GSE120500 Query DataSets for GSE120500
Status Public on Feb 13, 2019
Title PARP inhibition elicits STING-dependent antitumor immune responses in Brca1-deficient ovarian cancer
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary To examine the immune responses that occur in Brca1-deficent tumors upon olaparib treatment, we performed gene expression analysis of a panel of 4604 cancer and immune-related genes in tumor tissues harvested from Brca1-deficient ovarian tumor-bearing mice after treatment with olaparib or vehicle. Transcriptome analysis showed that the expression of genes associated with immune response, T-cell activation and interferon-gamma(IFNgamma) response were markedly upregulated in tumors treated with olaparib as compared to vehicle. Our data reveal the antitumor immune response of PARP inhibition and demonstrate that it contributes to therapeutic efficacy of PARP inhibition in Brca1-deficient tumors.
Overall design Transcriptome analysis were performed on bulk tumors collected from Brca1-deficient ovarian tumor bearimg mice treated with olaparib or vehicle control.
Contributor(s) Ding L, Zhao JJ
Citation(s) 30540933
Submission date Sep 26, 2018
Last update date Feb 13, 2019
Contact name Jean Zhao
Organization name Dana-Farber Cancer Institute
Department Cancer Biology
Street address 450 Brookline Ave
City Boston
State/province MA
ZIP/Postal code 02215
Country USA
Platforms (1)
GPL18635 Ion Torrent Proton (Mus musculus)
Samples (12)
GSM3401781 Control-1
GSM3401782 Control-2
GSM3401783 Control-3
BioProject PRJNA493223
SRA SRP162651

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Supplementary file Size Download File type/resource
GSE120500_Mouse_Transcriptome_control_and_parpi.xls.gz 185.9 Kb (ftp)(http) XLS
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