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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 07, 2018 |
| Title |
RNA expression data from hepatocytes from WT, NemoLPC-KO, Cxcr6-/- and NemoLPC-KOCxcr6-/- mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We investigated the role of CXCR6 in the NEMOLPC-KO mouse model. Genetic deletion of CXCR6 enhanced hepatocyte death, inflammation and fibrosis in NEMOLPC-KO mice.
This study aimed at characterizing the transcriptomic changes in hepatocytes from these mice compared to controls.
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| Overall design |
11 total samples were analyzed.
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| Contributor(s) |
Wehr A, Liepelt A, Denecke B |
| Citation(s) |
30476545 |
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| Submission date |
Oct 11, 2018 |
| Last update date |
Mar 21, 2021 |
| Contact name |
Bernd Denecke |
| E-mail(s) |
bernd.denecke@rwth-aachen.de
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| Phone |
+49 241 8089918
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| Organization name |
RWTH Aachen University
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| Department |
IZKF Aachen
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| Street address |
Pauwelsstrasse 30
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| City |
Aachen |
| State/province |
NRW |
| ZIP/Postal code |
52074 |
| Country |
Germany |
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| Platforms (1) |
| GPL20775 |
[MTA-1_0] Affymetrix Mouse Transcriptome Array 1.0 [transcript (gene) CSV version] |
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| Samples (11)
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| GSM3426533 |
liver-specific knockout of Nemo [NemoLPC-KO] and CXCR6 knockout, biological replicate 1 |
| GSM3426534 |
liver-specific knockout of Nemo [NemoLPC-KO] and CXCR6 knockout, biological replicate 2 |
| GSM3426535 |
liver-specific knockout of Nemo [NemoLPC-KO] and CXCR6 knockout, biological replicate 3 |
| GSM3426536 |
CXCR6 knockout, biological replicate 1 |
| GSM3426537 |
CXCR6 knockout, biological replicate 2 |
| GSM3426538 |
CXCR6 knockout, biological replicate 3 |
| GSM3426539 |
liver-specific knockout of Nemo [NemoLPC-KO], biological replicate 1 |
| GSM3426540 |
liver-specific knockout of Nemo [NemoLPC-KO], biological replicate 2 |
| GSM3426541 |
liver-specific knockout of Nemo [NemoLPC-KO], biological replicate 3 |
| GSM3426542 |
Wildtype, biological replicate 1 |
| GSM3426543 |
Wildtype, biological replicate 2 |
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| Relations |
| BioProject |
PRJNA495804 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE121124_RAW.tar |
271.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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