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Series GSE121214 Query DataSets for GSE121214
Status Public on Jan 25, 2019
Title Transcription Factors Dlx1/2 Are Required for Making All Interneurons in the Olfactory Bulb [Dlx1/2]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Purpose: To assess changes in gene expression profiles from the E16.5 wild type littermate controls LGE and Dlx1/2-/- mutant mice LGE (lateral ganglionic eminence).
Methods: Total RNA was isolated and sequenced using an Illumina Hi-seq 2500. Raw data was analyzed using TopHat. Genes were considered significantly changed which perform fold-change>=2 and P value <= 0.05.
Results: Compared to controls, 804 genes were significantly down regulated, and 673 genes were up regulated in the RNA expression level of the mutant LGE.
Overall design LGE RNA profiles of E16.5 Wild type mouse brain and Dlx1/2-/- mutant mouse brain.
Contributor(s) Guo T, Liu G, Du H, Wen Y, Wei S, Li M, Tao G, Shang Z, Song X, Zhang Z, Xu Z, You Y, Chen B, Yoshikawa K, Rubenstein JL, Yang Z
Citation(s) 30796806
Submission date Oct 14, 2018
Last update date Mar 21, 2019
Contact name Guoping Liu
Phone 18521006300
Organization name Fudan University
Street address 138 Yi Xue Yuan Road
City Shanghai
ZIP/Postal code 200032
Country China
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (6)
GSM3428019 Wild type LGE rep1
GSM3428020 Wild type LGE rep2
GSM3428021 Wild type LGE rep3
This SubSeries is part of SuperSeries:
GSE121215 Dlx1/2 Are Central and Essential Components in the Transcriptional Code for Generating Olfactory Bulb Interneurons
BioProject PRJNA496340
SRA SRP165687

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE121214_Processed_data_Dlx12_mut.txt.gz 1.4 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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