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| Status |
Public on Jan 25, 2019 |
| Title |
Transcription Factors Dlx1/2 Are Required for Making All Interneurons in the Olfactory Bulb [Dlx1/2] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: To assess changes in gene expression profiles from the E16.5 wild type littermate controls LGE and Dlx1/2-/- mutant mice LGE (lateral ganglionic eminence).
Methods: Total RNA was isolated and sequenced using an Illumina Hi-seq 2500. Raw data was analyzed using TopHat. Genes were considered significantly changed which perform fold-change>=2 and P value <= 0.05.
Results: Compared to controls, 804 genes were significantly down regulated, and 673 genes were up regulated in the RNA expression level of the mutant LGE.
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| |
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| Overall design |
LGE RNA profiles of E16.5 Wild type mouse brain and Dlx1/2-/- mutant mouse brain.
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| |
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| Contributor(s) |
Guo T, Liu G, Du H, Wen Y, Wei S, Li M, Tao G, Shang Z, Song X, Zhang Z, Xu Z, You Y, Chen B, Yoshikawa K, Rubenstein JL, Yang Z |
| Citation(s) |
30796806 |
| |
| Submission date |
Oct 14, 2018 |
| Last update date |
Mar 21, 2019 |
| Contact name |
Guoping Liu |
| E-mail(s) |
gpliu@fudan.edu.cn
|
| Phone |
18521006300
|
| Organization name |
Fudan University
|
| Street address |
138 Yi Xue Yuan Road
|
| City |
Shanghai |
| ZIP/Postal code |
200032 |
| Country |
China |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE121215 |
Dlx1/2 Are Central and Essential Components in the Transcriptional Code for Generating Olfactory Bulb Interneurons |
|
| Relations |
| BioProject |
PRJNA496340 |
| SRA |
SRP165687 |
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