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Series GSE122165 Query DataSets for GSE122165
Status Public on Jan 01, 2020
Title A transcriptomic study of selenium against liver injury by RNA-seq
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Evidence from biochemical indicators suggested that selenium could effectively repair the liver injury caused by beta-cypermethrin (β-CYP). However, the molecular mechanisms of selenium against liver injury induced by β-CYP remains unclear. In the present study, dynamic changes in gene expression profiles before and after the treatment of Na2SeO3 in liver injury mice were analyzed by using RNA sequencing. As a result, several essential genes and pathways were identified to be significantly associated with this process.
Overall design The liver samples of mice are extracted from 3 groups, including the control group, the liver injury group with the treatment of 40mg/kg β-CYP, and the repair group with the treatment of 40mg/kg β-CYP and 50μg/kg Na2SeO3. RNA sequencing was performed by using the platform of Illumina HiSeq 3000. All experiments were performed in triplicates.
Web link
Contributor(s) He K, Tang Q, Gong M, Zhang J, Huang B
Citation(s) 31659573
Submission date Nov 05, 2018
Last update date Feb 02, 2020
Contact name Kan He
Organization name Anhui University
Department School of life sciences
Lab Center for Stem Cell and Translational Medicine
Street address 111 Jiulong Road
City Hefei
State/province Anhui
ZIP/Postal code 230601
Country China
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (9)
GSM3457133 Control rep1
GSM3457134 Control rep2
GSM3457135 Control rep3
BioProject PRJNA503871
SRA SRP167876

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE122165_gene_exp_with_symbol.txt.gz 1.6 Mb (ftp)(http) TXT
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Processed data are available on Series record

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