GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE123149 Query DataSets for GSE123149
Status Public on Dec 24, 2019
Title RNA-sequencing of murine WT and MAZR-cKO FOXP3+ regulatory T cells (Treg cells)
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The analysis of WT and MAZR-cKO mice indicates that the transcription factor MAZR plays an important role in Treg cell development and function. The aim of this NGS experiment was to determine the MAZR-dependent transcriptome in regulatory T cells to elucidate how MAZR controls Treg cell biology. The results of this genome-wide analysis indicate that MAZR-cKO Treg cells display only minor transcriptional differences, suggesting that MAZR has a minor role in establishing the transcriptional program in ex vivo analyzed Treg cells once the Treg cell fate has been acquired.
Overall design mRNA expression profiles of 6-8 week old splenic WT,DEREG and MAZR-cKO,DEREG (CD4-cre) mice were generated by deep sequencing.
Contributor(s) Andersen L, Ellmeier W
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Nov 29, 2018
Last update date Dec 24, 2019
Contact name Wilfried Ellmeier
Organization name Medical University of Vienna
Department Institute of Immunology
Street address Lazarettgase 19
City Vienna
ZIP/Postal code 1030
Country Austria
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (6)
GSM3496649 WT 1
GSM3496650 WT 2
GSM3496651 WT 3
BioProject PRJNA507642
SRA SRP171222

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE123149_Normalized_data_Treg.xlsx 4.8 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap