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Series GSE123149 Query DataSets for GSE123149
Status Public on Dec 24, 2019
Title RNA-sequencing of murine WT and MAZR-cKO FOXP3+ regulatory T cells (Treg cells)
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The analysis of WT and MAZR-cKO mice indicates that the transcription factor MAZR plays an important role in Treg cell development and function. The aim of this NGS experiment was to determine the MAZR-dependent transcriptome in regulatory T cells to elucidate how MAZR controls Treg cell biology. The results of this genome-wide analysis indicate that MAZR-cKO Treg cells display only minor transcriptional differences, suggesting that MAZR has a minor role in establishing the transcriptional program in ex vivo analyzed Treg cells once the Treg cell fate has been acquired.
 
Overall design mRNA expression profiles of 6-8 week old splenic WT,DEREG and MAZR-cKO,DEREG (CD4-cre) mice were generated by deep sequencing.
 
Contributor(s) Andersen L, Ellmeier W
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Submission date Nov 29, 2018
Last update date Dec 24, 2019
Contact name Wilfried Ellmeier
E-mail(s) wilfried.ellmeier@meduniwien.ac.at
Organization name Medical University of Vienna
Department Institute of Immunology
Street address Lazarettgase 19
City Vienna
ZIP/Postal code 1030
Country Austria
 
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (6)
GSM3496649 WT 1
GSM3496650 WT 2
GSM3496651 WT 3
Relations
BioProject PRJNA507642
SRA SRP171222

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE123149_Normalized_data_Treg.xlsx 4.8 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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