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Series GSE12360 Query DataSets for GSE12360
Status Public on Nov 04, 2008
Title Genome-wide analysis of H3K79 methylation in CD34+ CD19+ cells from normal marrow, MLL-rearranged or MLL-germline ALL
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by genome tiling array
Summary We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). ChIP-chip analysis demonstrated increased histone H3 Lysine 79 (H3K79) dimethylation that correlated with Mll-AF4 associated gene expression profiles in murine ALLs, and in human MLL-rearranged leukemias. In addition, human MLL-rearranged ALLs can be distinguished from other ALLs by their genome-wide H3K79 methylation profiles.

Keywords: Cell type comparison
Overall design DNA immunoprecipitated with anti-dimethyl-H3K79 antibodies from normal CD34+CD19+ cells, leukemic bone marrow from MLL-rearranged ALL or MLL-germline ALL was hybridized to Affymetrix promoter tiling microarrays.
Contributor(s) Lemieux ME
Citation(s) 18977325
Submission date Aug 06, 2008
Last update date Jan 21, 2015
Contact name Madeleine E. Lemieux
Phone 617-595-6695
Organization name Bioinfo
Street address 275 Main St., Suite 252
City Plantagenet
State/province ON
ZIP/Postal code K0B 1L0
Country Canada
Platforms (1)
GPL5082 [Hs_PromPR] Affymetrix Human Promoter 1.0R Array
Samples (3)
GSM310413 CD34_CD19_H3K79 (5 samples)
GSM310414 MLL-rearranged_ALL_H3K79 (5 samples)
GSM310415 MLL-germline_ALL_H3K79 (7 samples)
This SubSeries is part of SuperSeries:
GSE12363 H3K79 methylation profiles define murine and human MLL-AF4 leukemias
BioProject PRJNA114197

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE12360_Hs_PromPR_v01-3_NCBIv36.NR.bpmap 140.7 Mb (ftp)(http) BPMAP
GSE12360_RAW.tar 382.4 Mb (http)(custom) TAR (of BAR, BED, CEL)
Processed data provided as supplementary file

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