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Series GSE12512 Query DataSets for GSE12512
Status Public on Jan 01, 2016
Title Expression Profiling in Human Osteosarcoma
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Osteosarcoma is a rare, highly malignant tumor of the bone that presents with a highly complex and abnormal karyotype. Only a few of the genes, which are targets of genetic alteration are known. An integrated genome-wide genomic and gene expression profiling analysis was performed on human osteosarcoma tissues and osteosarcoma cell lines in order to identify and map, in a high-resolution fashion, the most drastic chromosomal changes and point out genes which could contribute to tumorigenesis by having altered expression levels of critical oncogenes and tumor suppressors. Combined gene expression and aCGH analysis on the same samples enables direct comparison between DNA and mRNA level and offers a general strategy to identify and prioritize potential targets while the parallel analysis on cell lines offers a reliable models for further functional studies.
 
Overall design Gene expression profiling analysis was performed on 27 osteosarcoma tumors, 12 OS cell lines and 8 leiomyosarcoma tumors
 
Contributor(s) Scrimieri F, Walker RL, Meltzer PS
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Submission date Aug 21, 2008
Last update date Jan 01, 2016
Contact name Yuelin Jack Zhu
E-mail(s) zhujack@mail.nih.gov
Phone (240)760-7439
Organization name NCI
Department Genetics Branch, Center for Cancer Research
Lab Dr. Paul Meltzer's Lab
Street address 9000 Rockville Pike
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
 
Platforms (2)
GPL7192 Illumina HumanRef-8 Expression BeadChip
GPL7306 Illumina HumanRef-6 Expression BeadChip
Samples (47)
GSM314344 Osteosarcoma tumor - 20772 (expression)
GSM314345 Osteosarcoma tumor - 25712 (expression)
GSM314346 Osteosarcoma tumor - 26395 (expression)
This SubSeries is part of SuperSeries:
GSE12805 Osteosarcoma (expression, HD aCGH, aCGH)
Relations
BioProject PRJNA114211

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE12512_combined_lumi_raw_081908.txt 87.3 Mb (ftp)(http) TXT
GSE12512_combined_vsn-rsn_normalized.txt 6.8 Mb (ftp)(http) TXT
GSE12512_lumi_Ref6_raw.txt 28.6 Mb (ftp)(http) TXT
GSE12512_lumi_Ref8_raw.txt 36.4 Mb (ftp)(http) TXT
GSE12512_readme.txt 1.5 Kb (ftp)(http) TXT
Processed data included within Sample table
Processed data provided as supplementary file
Processed data are available on Series record

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