|
Status |
Public on Jan 10, 2025 |
Title |
The effects of differential gut microbiota on hepatic gene expression |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
|
Summary |
Our preliminary data suggest that differential gut microbiota modulates acetaminophen-induced hepatotoxicity (APAP toxicity) in mice model. The goal of our study is to determine whether commensal gut microbiota modulates the hepatic gene expressions potentially responsible for modulating APAP toxicity.
|
|
|
Overall design |
Method: C57BL/6 male mice from two different vendors [Jackson (JAX) and Taconic (TAC)] were sacrificed and liver tissue collected. Cecum materials from JAX or TAC mice were inoculated to germ-free (GF) mice. After 4 weeks of conventionalization, mice were overnight fasted (16 h) and sacrificed for liver collection. Examination of 5 groups; JAX, TAC, GF, GF_JAX and GF_TAC
|
|
|
Contributor(s) |
Cho S, Chung E, Jeong H, Park J |
Citation missing |
Has this study been published? Please login to update or notify GEO. |
|
Submission date |
Jan 22, 2019 |
Last update date |
Jan 10, 2025 |
Contact name |
Joo-Seop Park |
Organization name |
Cincinnati Children's Hospital Medical Center
|
Street address |
3333 Burnet Avenue
|
City |
Cincinnati |
ZIP/Postal code |
45229 |
Country |
USA |
|
|
Platforms (1) |
GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
|
Samples (22)
|
|
Relations |
BioProject |
PRJNA516343 |
SRA |
SRP181112 |