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Series GSE125418 Query DataSets for GSE125418
Status Public on Jan 10, 2025
Title The effects of differential gut microbiota on hepatic gene expression
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Our preliminary data suggest that differential gut microbiota modulates acetaminophen-induced hepatotoxicity (APAP toxicity) in mice model. The goal of our study is to determine whether commensal gut microbiota modulates the hepatic gene expressions potentially responsible for modulating APAP toxicity.
 
Overall design Method: C57BL/6 male mice from two different vendors [Jackson (JAX) and Taconic (TAC)] were sacrificed and liver tissue collected. Cecum materials from JAX or TAC mice were inoculated to germ-free (GF) mice. After 4 weeks of conventionalization, mice were overnight fasted (16 h) and sacrificed for liver collection.
Examination of 5 groups; JAX, TAC, GF, GF_JAX and GF_TAC
 
Contributor(s) Cho S, Chung E, Jeong H, Park J
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Submission date Jan 22, 2019
Last update date Jan 10, 2025
Contact name Joo-Seop Park
Organization name Cincinnati Children's Hospital Medical Center
Street address 3333 Burnet Avenue
City Cincinnati
ZIP/Postal code 45229
Country USA
 
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (22)
GSM3573663 JAX1
GSM3573664 JAX2
GSM3573665 JAX3
Relations
BioProject PRJNA516343
SRA SRP181112

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Supplementary file Size Download File type/resource
GSE125418_RPKM.xlsx 4.2 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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