|
| Status |
Public on Feb 12, 2019 |
| Title |
Negative regulation of lymphoid specification by the transcription factor TAL1 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Lymphoid primed multipotent progenitors are a subset of MPPs that are undergoing specification to the lymphoid and myeloid cell fates. The transcription factors Lyl1 and E2A are both essential for the development LMPPs and can form a heterodimeric complex. We examined the consequences of E2A- or Lyl1-deficiency on development of LMPPs and on their gene expression program in comparison with wild-type LMPPs
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| |
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| Overall design |
Examination of RNA present in Rag2-GFP+ and Rag2-GFP- HSC and LMPP isolated from control and VaviCre Tal1floxed/floxed mice.
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| Contributor(s) |
dePooter R, Dias S, Bartom ET, Okoreeh MK, Sigvardsson M, Kee BL |
| Citation(s) |
30962294 |
| |
| Submission date |
Feb 11, 2019 |
| Last update date |
May 15, 2019 |
| Contact name |
Barbara L Kee |
| Organization name |
The University of Chicago
|
| Department |
Pathology
|
| Street address |
924 E57th st
|
| City |
Chicago |
| State/province |
Illinois |
| ZIP/Postal code |
60637 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA521778 |
| SRA |
SRP185546 |
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