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Series GSE126402 Query DataSets for GSE126402
Status Public on Feb 12, 2019
Title Negative regulation of lymphoid specification by the transcription factor TAL1
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Lymphoid primed multipotent progenitors are a subset of MPPs that are undergoing specification to the lymphoid and myeloid cell fates. The transcription factors Lyl1 and E2A are both essential for the development LMPPs and can form a heterodimeric complex. We examined the consequences of E2A- or Lyl1-deficiency on development of LMPPs and on their gene expression program in comparison with wild-type LMPPs
Overall design Examination of RNA present in Rag2-GFP+ and Rag2-GFP- HSC and LMPP isolated from control and VaviCre Tal1floxed/floxed mice.
Contributor(s) dePooter R, Dias S, Bartom ET, Okoreeh MK, Sigvardsson M, Kee BL
Citation(s) 30962294
Submission date Feb 11, 2019
Last update date May 15, 2019
Contact name Barbara L Kee
Organization name The University of Chicago
Department Pathology
Street address 924 E57th st
City Chicago
State/province Illinois
ZIP/Postal code 60637
Country USA
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (24)
GSM3597792 Ctrl_HSC_Rag2GFPneg_1
GSM3597793 Ctrl_HSC_Rag2GFPneg_2
GSM3597794 Ctrl_HSC_Rag2GFPneg_3
BioProject PRJNA521778
SRA SRP185546

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Supplementary file Size Download File type/resource
GSE126402_htseq.reordered.normCounts.txt.gz 2.3 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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