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Series GSE126996 Query DataSets for GSE126996
Status Public on Apr 23, 2019
Title Altered Glutamate Receptor Ionotropic Delta Subunit 2 expression in Stau2 deficient cerebellar Purkinje cells in the adult brain
Organism Mus musculus
Experiment type Expression profiling by array
Summary Staufen2 (Stau2) is an RNA-binding protein that is involved in dendritic spine morphogenesis and function. Several studies have recently investigated the role of Stau2 in the regulation of its neuronal target mRNAs, with particular focus on the hippocampus. Here, we provide evidence for Stau2 expression and function in cerebellar Purkinje cells. We show that Stau2 downregulation (Stau2GT) lead to an increase of the glutamate receptor ionotropic delta subunit 2 (GluD2) in Purkinje cells when animals performed physical activity by voluntary wheel running. Furthermore, Stau2GT mice showed lower performance in motor coordination assays but enhanced motor learning abilities, concomitantly with an increase in dendritic GluD2 expression. Together, our results suggest a novel role of Stau2 in Purkinje cell synaptogenesis in the mouse cerebellum
 
Overall design Total RNA isolated from wildtype and Stau2 knockout mice brain before and after behavioural training.
 
Contributor(s) Pernice HF, Schieweck R, Jafari M, Straub T, Bilban M, Kiebler MA, Popper B
Citation(s) 30979012
Submission date Feb 25, 2019
Last update date Apr 25, 2019
Contact name Tobias Straub
E-mail(s) tstraub@med.uni-muenchen.de
Organization name LMU Munich
Department Biomedical Center, Bioinformatics
Street address GroƟhadener Str. 9
City Martinsried
ZIP/Postal code 82152
Country Germany
 
Platforms (1)
GPL16570 [MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version]
Samples (12)
GSM3619582 naive wildtype mice, replicate 1
GSM3619583 naive wildtype mice, replicate 2
GSM3619584 naive wildtype mice, replicate 3
Relations
BioProject PRJNA524119

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Supplementary file Size Download File type/resource
GSE126996_RAW.tar 107.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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