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Series GSE128053 Query DataSets for GSE128053
Status Public on Mar 15, 2019
Title A homeostasis hypothesis of avian influenza resistance in chickens
Organism Gallus gallus
Experiment type Methylation profiling by high throughput sequencing
Summary Avian influenza caused significant damages to the poultry industry, efforts have been made to reveal the disease mechanisms as well as mechanisms of disease resistance. Here, by investigating two chicken breeds with distinct responses to avian influenza virus (AIV), Leghorn GB2 and Fayoumi M43, we compared their differences in genome, methylation and transcriptome. Except for MX1 involved direct acting antiviral mechanism, we found that in both methylation and transcriptome levels the more AIV resistant breed Fayoumi showed less variations compared to White Leghorn after AIV challenging. Fayoumi also showed better consistency between the changes in methylation and changes in transcriptome level. Our results suggested a homeostasis hypothesis of avian influenza resistance, with Fayoumi better maintaining homeostasis both in epigenetic and gene expression levels.
Overall design DNA methylation profiles of two highly inbred chicken lines, Leghorn and Fayoumi, which were generated by deep sequencing, using Illumina GAII.
Contributor(s) An J, Li J
Citation(s) 31319606
Submission date Mar 08, 2019
Last update date Aug 27, 2019
Contact name Jing An
Organization name Universite Paris Saclay
Street address 630 Rue Noetzlin
City Paris
ZIP/Postal code 91190
Country France
Platforms (1)
GPL9385 Illumina Genome Analyzer II (Gallus gallus)
Samples (8)
GSM3671352 Leghorn biological replicate1 individual injected with avian influenza virus [LI1-B]
GSM3671353 Leghorn biological replicate1 individual injected with avian influenza virus [LI1-C]
GSM3671354 Leghorn biological replicate2 individual injected with avian influenza virus [LI2-A]
BioProject PRJNA527115
SRA SRP188450

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE128053_RAW.tar 1007.8 Mb (http)(custom) TAR (of COV)
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Raw data are available in SRA
Processed data provided as supplementary file

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