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| Status |
Public on Nov 28, 2019 |
| Title |
Large B-Cell Lymphomas in Pediatric and Young Adults Display Clinically Relevant Molecular Features Distinguishable from Adult Counterparts [cytoscan] |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by genome tiling array
Genome variation profiling by SNP array
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| Summary |
Pediatric aggressive large B-cell lymphomas (LBCL) share morphological and phenotypic features with adult types but seem to have better prognosis. Additionally, a specific subtype carrying IRF4 translocations (LBCL-IRF4) has been recently identified in this age group.
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| Overall design |
The aim of this study was to perform a complete genetic characterization of 60 Large B-cell lymphomas (LBCL) in pediatric and young adult population including LBCL with IRF4 rearrangement (LBCL-IRF4). Twenty-one LBCL-IRF4 cases, 10 High grade B-cell lymphoma, not otherwise specified, 29 diffuse large B-cell lymphoma and 6 relapsed cases with consensus diagnosis were analyzed by fluorescence in situ hybridization, copy number array, gene expression and targeted sequencing analyses of genes associated with B-cell lymphoma pathology.
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| Contributor(s) |
Gonzalez-Farre B, Ramis-Zaldivar JE, Salmerón-Villalobos J, Campo E, Salaverria I |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Mar 13, 2019 |
| Last update date |
Nov 30, 2019 |
| Contact name |
Joan Enric Ramiz-Zaldivar |
| E-mail(s) |
ramis@clinic.cat
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| Phone |
+34 932275400
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| Organization name |
IDIBAPS
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| Department |
Molecular Pathology Laboratory
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| Lab |
Centre Esther Koplowitz (CEK)
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| Street address |
Rosselló, 153
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| City |
Barcelona |
| ZIP/Postal code |
08036 |
| Country |
Spain |
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| Platforms (1) |
| GPL16131 |
[CytoScanHD_Array] Affymetrix CytoScan HD Array |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE128294 |
Large B-Cell Lymphomas in Pediatric and Young Adults Display Clinically Relevant Molecular Features Distinguishable from Adult Counterparts |
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| Relations |
| BioProject |
PRJNA527033 |
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