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Series GSE128289 Query DataSets for GSE128289
Status Public on Aug 22, 2019
Title Environmental Factors Influence the Epigenetic Signature of Newborns from Mothers with Gestational Diabetes
Organism Homo sapiens
Experiment type Methylation profiling by high throughput sequencing
Summary Here we investigated the degree by which epigenetic signatures in children from mothers with obesity or gestational diabetes mellitus are influenced by environmental factors. We profiled the DNA methylation signature of whole blood from lean, obese and gestational diabetes mellitus mothers and their respective newborns. DNA methylation profiles of mothers showed high similarity across groups, while on the contrary, newborns from GDM mothers showed a marked distinct epigenetic profile compared to newborns of both lean and obese mothers. Analysis of variance in DNA methylation levels between newborns showed higher variance in the GDM group. Our work suggest that environmental factors, rather than direct transmission of epigenetic marks from the mother, are involved in establishing the epigenetic signature associated with GDM.
 
Overall design We performed Reduced Representation Bisulfite Sequencing on 8 lean, 8 obese and 8 gestational diabetic mother-newborn pairs.
 
Contributor(s) Andersen E, Altıntaş A, Andersson-Hall U, Holmäng A, Barrès R
Citation(s) 30966798
Submission date Mar 14, 2019
Last update date Aug 24, 2019
Contact name Lars Roed Ingerslev
E-mail(s) ingerslev@sund.ku.dk
Organization name Copenhagen University
Department NNF Center for Basic Metabolic Research
Lab Integrative Physiology
Street address Blegdamsvej 3B
City Copenhagen
ZIP/Postal code 2200
Country Denmark
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (48)
GSM3670691 OB_B_5
GSM3670692 OB_B_6
GSM3670693 OB_B_7
Relations
BioProject PRJNA527032
SRA SRP188419

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE128289_RAW.tar 977.9 Mb (http)(custom) TAR (of COV)
GSE128289_clinical_data.xlsx 30.7 Kb (ftp)(http) XLSX
GSE128289_imputed_methylationMatrix.txt.gz 122.0 Mb (ftp)(http) TXT
GSE128289_raw_methylationMatrix.txt.gz 115.2 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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