|
| Status |
Public on Nov 28, 2019 |
| Title |
Large B-Cell Lymphomas in Pediatric and Young Adults Display Clinically Relevant Molecular Features Distinguishable from Adult Counterparts [Nanostring] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Pediatric aggressive large B-cell lymphomas (LBCL) share morphological and phenotypic features with adult types but seem to have better prognosis. Additionally, a specific subtype carrying IRF4 translocations (LBCL-IRF4) has been recently identified in this age group.
|
| |
|
| Overall design |
The aim of this study was to perform a complete genetic characterization of 60 Large B-cell lymphomas (LBCL) in pediatric and young adult population including LBCL with IRF4 rearrangement (LBCL-IRF4). Twenty-one LBCL-IRF4 cases, 10 High grade B-cell lymphoma, not otherwise specified, 29 diffuse large B-cell lymphoma and 6 relapsed cases with consensus diagnosis were analyzed by fluorescence in situ hybridization, copy number array, gene expression and targeted sequencing analyses of genes associated with B-cell lymphoma pathology.
|
| |
|
| Contributor(s) |
Gonzalez-Farre B, Ramis-Zaldivar JE, Salmerón-Villalobos J, Campo E, Salaverria I |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Mar 14, 2019 |
| Last update date |
Nov 30, 2019 |
| Contact name |
Joan Enric Ramiz-Zaldivar |
| E-mail(s) |
ramis@clinic.cat
|
| Phone |
+34 932275400
|
| Organization name |
IDIBAPS
|
| Department |
Molecular Pathology Laboratory
|
| Lab |
Centre Esther Koplowitz (CEK)
|
| Street address |
Rosselló, 153
|
| City |
Barcelona |
| ZIP/Postal code |
08036 |
| Country |
Spain |
| |
|
| Platforms (1) |
| GPL19965 |
nCounter PanCancer Immune Profiling Panel |
|
| Samples (21)
|
|
| This SubSeries is part of SuperSeries: |
| GSE128294 |
Large B-Cell Lymphomas in Pediatric and Young Adults Display Clinically Relevant Molecular Features Distinguishable from Adult Counterparts |
|
| Relations |
| BioProject |
PRJNA527036 |
Less...
More...