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Status |
Public on Aug 20, 2020 |
Title |
Neonatal hematopoietic stem and progenitor cell ontogeny at single cell resolution (ATAC-seq) |
Organism |
Mus musculus |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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Summary |
The goal of this study was to characterize the transcriptional changes that take place in hematopoietic stem and progenitor cells as they transit the neonatal period of development. These changes were observed at the single cell level and they are correlated with epigenome remodeling, as evidenced by the ATAC-seq and Chipmentation data (H3K4me1 and H3K27ac) in this data set.
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Overall design |
(i) ATAC-seq analysis of HSCs and HPCs during fetal, neonatal and adult stages of development (ii) ATAC-seq analysis of wild type and Ifnar-ko HSCs and HPCs at P7 The strain background for all experiments is B6
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Contributor(s) |
Magee J |
Citation(s) |
32822583 |
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Submission date |
Mar 24, 2019 |
Last update date |
Nov 23, 2020 |
Contact name |
Jeffery Magee |
E-mail(s) |
magee_j@kids.wustl.edu
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Organization name |
Washington University School of Medicine
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Department |
Internal Medicine - Cardiovascular Division
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Street address |
660 S Euclid Ave.
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City |
St Louis |
State/province |
Missouri |
ZIP/Postal code |
63110 |
Country |
USA |
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Platforms (1) |
GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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Samples (35)
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This SubSeries is part of SuperSeries: |
GSE128762 |
Neonatal hematopoietic stem and progenitor cell ontogeny at single cell resolution |
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Relations |
BioProject |
PRJNA528803 |
SRA |
SRP189265 |
Supplementary file |
Size |
Download |
File type/resource |
GSE128758_BA_P7_48+LSK.fc.signal.bigwig |
481.0 Mb |
(ftp)(http) |
BIGWIG |
GSE128758_BA_P7_48+LSK.optimal_peak.narrowPeak.gz |
2.2 Mb |
(ftp)(http) |
NARROWPEAK |
GSE128758_BA_P7_HSC.fc.signal.bigwig |
396.0 Mb |
(ftp)(http) |
BIGWIG |
GSE128758_BA_P7_HSC.optimal_peak.narrowPeak.gz |
1.6 Mb |
(ftp)(http) |
NARROWPEAK |
GSE128758_Infnar_mm__P7_48+LSK.fc.signal.bigwig |
491.4 Mb |
(ftp)(http) |
BIGWIG |
GSE128758_Infnar_mm__P7_48+LSK.optimal_peak.narrowPeak.gz |
2.1 Mb |
(ftp)(http) |
NARROWPEAK |
GSE128758_Infnar_mm__P7_HSC.fc.signal.bigwig |
197.1 Mb |
(ftp)(http) |
BIGWIG |
GSE128758_Infnar_mm__P7_HSC.optimal_peak.narrowPeak.gz |
1.4 Mb |
(ftp)(http) |
NARROWPEAK |
GSE128758_P14_HPC.filt.narrowPeak.gz |
2.8 Mb |
(ftp)(http) |
NARROWPEAK |
GSE128758_P14_HPC.pooled.fc.signal.bigwig |
676.8 Mb |
(ftp)(http) |
BIGWIG |
GSE128758_P14_HSC.filt.narrowPeak.gz |
2.7 Mb |
(ftp)(http) |
NARROWPEAK |
GSE128758_P14_HSC.pooled.fc.signal.bigwig |
348.9 Mb |
(ftp)(http) |
BIGWIG |
GSE128758_P21_HPC.filt.narrowPeak.gz |
2.3 Mb |
(ftp)(http) |
NARROWPEAK |
GSE128758_P21_HPC.pooled.fc.signal.bigwig |
429.8 Mb |
(ftp)(http) |
BIGWIG |
GSE128758_P7_HPC.filt.narrowPeak.gz |
2.2 Mb |
(ftp)(http) |
NARROWPEAK |
GSE128758_P7_HPC.pooled.fc.signal.bigwig |
336.4 Mb |
(ftp)(http) |
BIGWIG |
GSE128758_adult_HPC.filt.narrowPeak.gz |
2.6 Mb |
(ftp)(http) |
NARROWPEAK |
GSE128758_adult_HPC.pooled.fc.signal.bigwig |
768.6 Mb |
(ftp)(http) |
BIGWIG |
GSE128758_adult_HSC.filt.narrowPeak.gz |
3.1 Mb |
(ftp)(http) |
NARROWPEAK |
GSE128758_adult_HSC.pooled.fc.signal.bigwig |
1006.3 Mb |
(ftp)(http) |
BIGWIG |
GSE128758_fetal_HPC.filt.narrowPeak.gz |
2.7 Mb |
(ftp)(http) |
NARROWPEAK |
GSE128758_fetal_HPC.pooled.fc.signal.bigwig |
706.4 Mb |
(ftp)(http) |
BIGWIG |
GSE128758_fetal_HSC.filt.narrowPeak.gz |
3.1 Mb |
(ftp)(http) |
NARROWPEAK |
GSE128758_fetal_HSC.pooled.fc.signal.bigwig |
693.8 Mb |
(ftp)(http) |
BIGWIG |
SRA Run Selector |
Raw data are available in SRA |
Processed data are available on Series record |