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Series GSE129414 Query DataSets for GSE129414
Status Public on Mar 02, 2020
Title RXRs are required for neonatal expansion of the serosal macrophage pool and contribute to ovarian cancer progression
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Distinct macrophage populations throughout the body display highly heterogeneous transcriptional and epigenetic programs. However, the regulation of chromatin accessibility of tissue-resident macrophages is poorly understood. In this study, we generated a data set for genome-wide transposase-accessible chromatin analysis (ATAC-seq) of large peritoneal macrophages in animals with myeloid-specific double deletion of the nuclear receptors RXRa and RXRb.
Overall design The chromatin accessibility profiles of sorted large peritoneal macrophages (LPMs) from 9-week-old wild type (WT) and RXRa/RXRb-deficient (KO) mice were generated by deep sequencing in duplicate using 2×50 HiSeq 3000 (Illumina) and with an average of 25 million paired-end reads per sample.
Contributor(s) Ricote M
Citation(s) 32246014
Submission date Apr 05, 2019
Last update date Apr 13, 2020
Contact name Mercedes Ricote
Organization name CNIC
Street address Melchor Fernández Almagro, 3
City Madrid
ZIP/Postal code 28029
Country Spain
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (4)
GSM3712655 WT1
GSM3712656 WT3
GSM3712657 KO1
BioProject PRJNA531202
SRA SRP191150

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE129414_RAW.tar 4.6 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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