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Series GSE131307 Query DataSets for GSE131307
Status Public on Feb 04, 2021
Title GAS7 Deficiency Promotes Metastasis of MYCN-driven Neuroblastoma
Organism Danio rerio
Experiment type Expression profiling by high throughput sequencing
Summary Neuroblastoma (NB), the most common extracranial solid tumor in children, often metastasizes at a high rate. Here, we demonstrate that loss of function of the growth arrest-specific 7 gene (GAS7), located on Chr17p13.1, a deleted region in a subset of high-risk NB, accelerates dissemination of MYCN-overexpressing tumor cells in both zebrafish and xenografted mice models. Transcriptomic analysis of neuroblasotma tumors isolated from transgenic zebrafish overexpressing MYCN oncogene alone or MYCN with knockout of gas7 gene revealed that gene signitures affecting tumor cell-cell or cell-extracellular matrix interactions are significantly downregulated in tumors with gas7 loss of function. Our results provide the first genetic evidence that loss of function of a gene located in the Chr17p region contributes significantly to NB metastasis.
Overall design Examination of the transcriptomic profiles of neuroblastomas arose from transgenic fish overexpressing MYCN alone or MYCN with knockout of gas7.
Contributor(s) Zhu S, Li H
Citation(s) 33602789
Submission date May 16, 2019
Last update date Mar 29, 2021
Contact name Hu Li
Organization name Mayo Clinic
Department Molecular Pharmacology & Experimental Therapeutics
Lab Systems Biology and Pharmacology
Street address 200 First Street, Gonda Building G19-408
City Rochester
State/province MN
ZIP/Postal code 55904
Country USA
Platforms (1)
GPL14875 Illumina HiSeq 2000 (Danio rerio)
Samples (6)
GSM3768989 MYCN_gas7mut_1
GSM3768990 MYCN_gas7mut_2
GSM3768991 MYCN_gas7mut_3
BioProject PRJNA543225
SRA SRP198600

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Supplementary file Size Download File type/resource
GSE131307_counts.txt.gz 212.4 Kb (ftp)(http) TXT
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