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Series GSE131500 Query DataSets for GSE131500
Status Public on Feb 04, 2021
Title RNA seq on tumors from two groups of mice myofibroblast-collagen1 knockout group and control group)
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary RNA sequencing analysis on tumor samples from two groups of mice (1) KPPF;Col1smaKO myfibroblast-collagen1 knockout group and (2) KPPF control group. Collagen1 is the most abundant extracellular matrix protein component in desmoplastic pancreatic tumors. In this study, we establish the transgenic mouse model KPPF;Col1smaKO mice with pancreatic tumors deleted for myofibroblast-derived collagen1. Then we use RNA-seq to examine the global changes of gene expression profile in tumors of KPPF;Col1smaKO mice (as compared to control KPPF mice).
Overall design A total of 7 RNA samples from tumors from two groups of age-matched mice (1) KPPF;Col1smaKO myfibroblast-collagen1 knockout group, 4 mice; and (2) KPPF control group, 3 mice.
Contributor(s) Chen Y, Kalluri R
Citation(s) 33667385
Submission date May 20, 2019
Last update date May 06, 2021
Contact name Yang Chen
Organization name UT-MD Anderson Cancer Center
Department Cancer Biology
Street address 1881 East Road
City Houston
State/province Texas
ZIP/Postal code 77054
Country USA
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (7)
GSM3781757 KPPF mouse PDAC 1 [7-18-9]
GSM3781758 KPPF mouse PDAC 2 [7-18-11]
GSM3781760 KPPF mouse PDAC 3 [7-18-12]
BioProject PRJNA543852
SRA SRP198957

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Supplementary file Size Download File type/resource
GSE131500_YChen_KPPF.DES_norm.counts.txt.gz 976.8 Kb (ftp)(http) TXT
GSE131500_YChen_KPPF.raw.counts.txt.gz 306.1 Kb (ftp)(http) TXT
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