|
| Status |
Public on May 30, 2019 |
| Title |
Comparative transcriptomics between species attributes reactogenicity pathways induced by the capsular group B meningococcal vaccine, 4CMenB, to the membrane-bound endotoxin of its outer membrane vesicle component. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Whole blood RNA-seq was leveraged to explore gene expression changes induced in mice 24 hours after immunisation with a second dose of a licensed vaccine against capsular group B meningococcus, one of the vaccines components, or one of several comparator groups.
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| |
|
| Overall design |
mRNA was profiled from RNA extracted from mouse whole blood, 5-6 samples per group, using an Illumina HiSeq4000
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| |
|
| Contributor(s) |
Sheerin D |
| Citation(s) |
31551511 |
| |
| Submission date |
May 29, 2019 |
| Last update date |
Oct 10, 2019 |
| Contact name |
Dylan Sheerin |
| E-mail(s) |
dylan.sheerin@paediatrics.ox.ac.uk
|
| Organization name |
University of Oxford
|
| Department |
Paediatrics
|
| Lab |
Oxford Vaccine Group
|
| Street address |
Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital
|
| City |
Oxford |
| ZIP/Postal code |
OX37LJ |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
|
| Samples (59)
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|
| Relations |
| BioProject |
PRJNA545310 |
| SRA |
SRP199768 |
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