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| Status |
Public on Jun 27, 2019 |
| Title |
Angptl8 mediates food-driven resetting of hepatic circadian clock in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Mammalian circadian clocks precisely control the rhythms of behavior and physiology, and can be reset by various environmental signals. While the light-dark (LD) cycle resets the master clock, timed food intake is a potent synchronizer of peripheral clocks. As the largest metabolic organ, the liver sensitively responds to the food signals and secrets hepatokines, leading to the robust regulation of metabolic and clock processes. However, it remains unknown which hepatokine mediates the food-driven resetting of the liver clock independent of the master clock. In our current study, we clustered high-throughput RNA sequencing results to screen out candidate genes that mediate the food-driven resetting of the liver clock
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| Overall design |
Total RNA after subjecting to fasting/re-feeding cycles or constant darkness were isolated from mice liver and seqenced using Illumina HiSeq 3000
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| Contributor(s) |
Chen S, Feng M, Zhang S, Dong Z, Wang Y, Zhang W |
| Citation(s) |
31388006, 32160860 |
| |
| Submission date |
Jun 26, 2019 |
| Last update date |
Mar 17, 2020 |
| Contact name |
siyu chen |
| E-mail(s) |
siyuchen@cpu.edu.cn
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| Organization name |
China Pharmaceutical University
|
| Street address |
#639 longmian avenue
|
| City |
nanjing |
| ZIP/Postal code |
211198 |
| Country |
China |
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| Platforms (1) |
| GPL21493 |
Illumina HiSeq 3000 (Mus musculus) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA551214 |
| SRA |
SRP212112 |
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