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Series GSE13588 Query DataSets for GSE13588
Status Public on Mar 02, 2009
Title Gene expression in striatums of Foxp2-hum, Foxp2-ko and wild-type mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution due to effects on aspects of speech and language. Here, we introduce these substitutions into the endogenous Foxp2 gene.of mice. Although these mice are generally healthy, they have qualitatively different ultrasonic vocalizations, decreased exploratory behavior and decreased dopamine concentrations in the brain suggesting an effect of the humanized Foxp2 allele on basal ganglia. In the striatum, a part of the basal ganglia that is affected in humans with a speech deficit due to one non-functional FOXP2 allele, we find that medium spiny neurons have increased dendrite lengths and increased synaptic plasticity. Since mice carrying one non-functional Foxp2 allele show opposite effects, this suggests that alterations in cortico-basal ganglia circuits might have been important for the evolution of speech and language in humans. In this particular experiment, we investigate the effects of human Foxp2 (Foxp2hum) and the non-functional Foxp2 allele on striatal gene expression in embryonic, young and adult mice.
 
Overall design We determined genome-wide gene expression patterns in striatal biopsies from Foxp2hum/hum, Foxp2wt/ko and Foxp2wt/wt mice using high-density oligonucleotide arrays. The animals were derived from two independent FoxP2 knock-in strains and one knock-out strain. In total 71 animals were used, 29 males and 42 females. The mice ages were E16.5, P15, P18, P21 and P95 when sacrificed. The microarrays were processed in totally six batches.
 
Contributor(s) Somel M, Enard W, Gehre S, Hammerschmidt K, Hölter SM, Blass T, Brückner MK, Schreiweis C, Winter C, Sohr R, Becker L, Wiebe V, Nickel B, Giger T, Müller U, Pääbo S
Citation(s) 19490899
Submission date Nov 13, 2008
Last update date Mar 20, 2012
Contact name Mehmet Somel
E-mail(s) somel@eva.mpg.de
Phone +49-(0)341-3550-530
Fax +49-(0)341-3550-555
Organization name Max Planck Institute for Evolutionary Anthropology
Department Evolutionary Genetics
Street address Deutscher Platz 6
City Leipzig
ZIP/Postal code D-04103
Country Germany
 
Platforms (1)
GPL7635 Mouse Genome 430 2.0 Array [ENSG build 46 (v10) CDF]
Samples (71)
GSM341875 Foxp2hum/hum_strKi_15d_f_run2_litter5
GSM341876 Foxp2hum/hum_strKi_15d_f_run3_litter5
GSM341877 Foxp2hum/hum_strKi_15d_m_run1_litter6
Relations
BioProject PRJNA110695

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE13588_RAW.tar 451.0 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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