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Series GSE136955 Query DataSets for GSE136955
Status Public on Dec 06, 2020
Title Differential gene expression during embryoid body (EB) formation of mouse embryonic stem cells when Hnrnpll was depleted
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary This work indicates Hnrnpll depletion mES cells cannot exit from pluripotency programme, showing embryoid body formation deficiency and no spontaneous differentiation withdraw LIF. Hnrnpll promotes multiple ES cell preferred-exon skipping during ES cells differentiation, to reduce the ES cells specific isoform and facilitate ES cells exit from pluripotency towards differentiation.
Overall design polyA+ RNA profiles of wildtype or Hnrnpll-/- mESC EB differentiation at day 0, 4, 8.
Contributor(s) Wang X, Ping C, Tan P, Wang D, Ma Y, Yu J, Huang Y
Citation(s) 33349972
Submission date Sep 05, 2019
Last update date Jan 30, 2021
Contact name Jia Yu
Organization name Peking Union Medical College
Street address Dong Dan San Tiao 5, Dongcheng District
City Beijing
ZIP/Postal code 100005
Country China
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (9)
GSM4063634 WT_ESC
GSM4063635 WT_EBD4
GSM4063636 WT_EBD8
BioProject PRJNA564112
SRA SRP220502

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE136955_RAW.tar 7.5 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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