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Series GSE137622 Query DataSets for GSE137622
Status Public on Sep 30, 2020
Title Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Epigenetic regulation of gene expression through histone modifications like methylation of various lysine residues are essential for embryonic development. Here we removed SETD2, a methyltransferase for histone 3 lysine 36 trimethylation (H3K36me3), in the developing dorsal forebrain in mice and show it is required for proper area patterning (arealization) of the neocortex and the formation of thalamo-cortico-thalamic circuits by maintaining the expression of clustered protocadherin (Pcdh) genes in an H3K36me3 methyltransferase-dependent manner. Moreover, the Setd2 mutant mice exhibit defects in social interaction, motor endurance and spatial memory, reminiscent of patients with the Sotos-like syndrome bearing SETD2 mutations.
Overall design H3K36me3 ChIP-seq profiles of E13.5 control and Emx1-Cre;Setd2 fl/fl mice cortex were generated by deep sequencing, in two replicates, using Illumina Hi-seq X Ten.
Contributor(s) Xu L, Zheng Y, Li X, Wang A, Huo D, Li Q, Wang S, Luo Z, Liu Y, Xu F, Wu X, Wu M, Zhou Y
Citation(s) 33523829
Submission date Sep 18, 2019
Last update date Feb 08, 2021
Contact name Lichao Xu
Organization name Wuhan University
Street address luojiashan
City Wuhan
ZIP/Postal code 430000
Country China
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (6)
GSM4083374 control rep1
GSM4083375 control rep2
GSM4083376 control input
BioProject PRJNA566085
SRA SRP222234

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Supplementary file Size Download File type/resource
GSE137622_RAW.tar 408.2 Mb (http)(custom) TAR (of BW)
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Raw data are available in SRA
Processed data provided as supplementary file

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