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Series GSE138010 Query DataSets for GSE138010
Status Public on Sep 30, 2020
Title Fosl1 regulates mesenchymal GBM plasticity
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Despite recent advances in genomic profiling techniques, the precise mechanisms controlling GBM subtypes and their plasticity are not fully unraveled. Here,using transcriptomic data of patient derived stem cell lines we found that FOSL1 is a master regulator of the MES subtype. Depletion of FOSL1 resulted in loss of themesenchymal gene signature (MGS) in mouse Kras-mutant neural stem cells and in human brain tumor stem cells.
 
Overall design Mouse neural stem cells (NSCs) from GFAP-Tva, LSL_Cas9; Trp53 lox/lox; GFAP-Crep1 mice were transduced with a KrasG12V mutant and then with either Control or Fosl1 gRNAs
 
Contributor(s) Squatrito M
Citation(s) 34399888
Submission date Sep 25, 2019
Last update date Aug 24, 2021
Contact name Massimo Squatrito
E-mail(s) msquatrito@cnio.es
Organization name Spanish National Research Center (CNIO)
Street address Calle Melchor Fernandez Almagro 3
City Madrid
ZIP/Postal code 28029
Country Spain
 
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (4)
GSM4096586 NSC_sgCtrl_1
GSM4096587 NSC_sgCtrl_2
GSM4096588 NSC_sgFosl1_1
Relations
BioProject PRJNA574145
SRA SRP223224

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Supplementary file Size Download File type/resource
GSE138010_m_squatrito_normalized_counts.csv.gz 415.7 Kb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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