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Series GSE138931 Query DataSets for GSE138931
Status Public on Apr 03, 2020
Title RNA-seq analysis of WT and NCOR1f/f,Cd4Cre naive CD4+ T cells
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The differentiation of naïve CD4+ T cells into T helper (Th) subsets is key for a functional immune response and has to be tightly controlled by transcriptional and epigenetic processes. However, the function of cofactors that connect gene-specific transcription factors with repressive chromatin-modifying enzymes in Th cells is yet unknown. Here we determined transcriptional changes in naive CD4+ T cells upon deletion of the cofactor NCOR1.
 
Overall design mRNA expression profiles of WT and NCOR1f/f,Cd4Cre naive CD4+ T cells were generated by deep sequencing.
 
Contributor(s) Hainberger D, Ellmeier W
Citation(s) 32318068
https://doi.org/10.3389/fimmu.2020.00579
Submission date Oct 16, 2019
Last update date Apr 27, 2020
Contact name Wilfried Ellmeier
E-mail(s) wilfried.ellmeier@meduniwien.ac.at
Organization name Medical University of Vienna
Department Institute of Immunology
Street address Lazarettgase 19
City Vienna
ZIP/Postal code 1030
Country Austria
 
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (6)
GSM4123840 naive_CD4_WT1 (RNA-seq)
GSM4123841 naive_CD4_WT2 (RNA-seq)
GSM4123842 naive_CD4_WT3 (RNA-seq)
This SubSeries is part of SuperSeries:
GSE138934 Role of NCOR1 in CD4+ T cells
Relations
BioProject PRJNA577833
SRA SRP225856

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE138931_RAW.tar 10.3 Mb (http)(custom) TAR (of TSV)
GSE138931_rnaseq_cuffdiff_genes_fpkm_replicates_Naive_Th1_Th17.tsv.gz 3.2 Mb (ftp)(http) TSV
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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