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Series GSE138933 Query DataSets for GSE138933
Status Public on Apr 03, 2020
Title RNA-seq analysis of WT and NCOR1f/f,Cd4Cre in vitro-generated Th17 cells
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The differentiation of naïve CD4+ T cells into T helper (Th) subsets is key for a functional immune response and has to be tightly controlled by transcriptional and epigenetic processes. However, the function of cofactors that connect gene-specific transcription factors with repressive chromatin-modifying enzymes in Th cells is yet unknown. Here we determined transcriptional changes in Th17 cells upon deletion of the cofactor NCOR1.
 
Overall design mRNA expression profiles of WT and NCOR1f/f,Cd4Cre in vitro-generated Th17 cells were generated by deep sequencing
 
Contributor(s) Hainberger D, Ellmeier W
Citation(s) 32318068
https://doi.org/10.3389/fimmu.2020.00579
Submission date Oct 16, 2019
Last update date Apr 27, 2020
Contact name Wilfried Ellmeier
E-mail(s) wilfried.ellmeier@meduniwien.ac.at
Organization name Medical University of Vienna
Department Institute of Immunology
Street address Lazarettgase 19
City Vienna
ZIP/Postal code 1030
Country Austria
 
Platforms (1)
GPL21103 Illumina HiSeq 4000 (Mus musculus)
Samples (6)
GSM4123852 Th17_WT1 (RNA-seq)
GSM4123853 Th17_WT2 (RNA-seq)
GSM4123854 Th17_WT3 (RNA-seq)
This SubSeries is part of SuperSeries:
GSE138934 Role of NCOR1 in CD4+ T cells
Relations
BioProject PRJNA577838
SRA SRP225858

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE138933_RAW.tar 10.2 Mb (http)(custom) TAR (of TSV)
GSE138933_rnaseq_cuffdiff_genes_fpkm_replicates_Naive_Th1_Th17.tsv.gz 3.2 Mb (ftp)(http) TSV
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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