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Series GSE138981 Query DataSets for GSE138981
Status Public on Mar 31, 2020
Title Analysis of NSL knockout brains
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary In the current study, we analyse the function of MOF-NSL complex in neural cells. We find that the NSL complex regulates metabolic networks in the brain.
 
Overall design Knockout of NSL complex members Mof, Kansl2 and Kansl3 was induced using the Nestin Cre. Neural cells, endothelial cells, pericytes and microglia were isolated by FACS. Gene expression analysed by RNA seq. and chromatin landscape via ChIP seq.
 
Contributor(s) Sheikh B, Akhtar A, Reschler G
Citation(s) 32541879
Submission date Oct 16, 2019
Last update date Jul 09, 2020
Contact name Asifa Akhtar
E-mail(s) akhtarlab_data@ie-freiburg.mpg.de
Organization name Max Planck Institute of Immunobiology and Epigenetics
Department Chromatin Regulation
Lab Akhtar Lab
Street address Stuebeweg 51
City Freiburg
ZIP/Postal code 79108
Country Germany
 
Platforms (2)
GPL19057 Illumina NextSeq 500 (Mus musculus)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (85)
GSM4125640 whole_brain_Cre_16
GSM4125641 whole_brain_Cre_18
GSM4125642 whole_brain_Cre_19
Relations
BioProject PRJNA577934
SRA SRP225948

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE138981_Cre172_WT_H4K16ac.filtered.log2ratio.over_Cre172_WT_input.bw 221.7 Mb (ftp)(http) BW
GSE138981_Cre172_WT_panH3.filtered.log2ratio.over_Cre172_WT_input.bw 233.4 Mb (ftp)(http) BW
GSE138981_Cre173_WT_H4K16ac.filtered.log2ratio.over_Cre173_WT_input.bw 193.8 Mb (ftp)(http) BW
GSE138981_Cre173_WT_panH3.filtered.log2ratio.over_Cre173_WT_input.bw 210.0 Mb (ftp)(http) BW
GSE138981_FA-treated_DESeq_results.tsv.gz 1.7 Mb (ftp)(http) TSV
GSE138981_FA-treated_gene_counts.tsv.gz 403.4 Kb (ftp)(http) TSV
GSE138981_M621_KO_H4K16ac.filtered.log2ratio.over_M621_KO_input.bw 164.7 Mb (ftp)(http) BW
GSE138981_M621_KO_panH3.filtered.log2ratio.over_M621_KO_input.bw 213.9 Mb (ftp)(http) BW
GSE138981_M622_WT_H4K16ac.filtered.log2ratio.over_M622_WT_input.bw 223.2 Mb (ftp)(http) BW
GSE138981_M622_WT_panH3.filtered.log2ratio.over_M622_WT_input.bw 236.3 Mb (ftp)(http) BW
GSE138981_M662_KO_H4K16ac.filtered.log2ratio.over_M662_KO_input.bw 159.5 Mb (ftp)(http) BW
GSE138981_M662_KO_panH3.filtered.log2ratio.over_M662_KO_input.bw 200.1 Mb (ftp)(http) BW
GSE138981_M663_KO_H4K16ac.filtered.log2ratio.over_M663_KO_input.bw 161.0 Mb (ftp)(http) BW
GSE138981_M663_KO_panH3.filtered.log2ratio.over_M663_KO_input.bw 213.7 Mb (ftp)(http) BW
GSE138981_M666_WT_H4K16ac.filtered.log2ratio.over_M666_WT_input.bw 250.2 Mb (ftp)(http) BW
GSE138981_M666_WT_panH3.filtered.log2ratio.over_M666_WT_input.bw 264.8 Mb (ftp)(http) BW
GSE138981_endo_kansl2_vs_cre_DEseq_basic_DEresults.tsv.gz 1.5 Mb (ftp)(http) TSV
GSE138981_endo_kansl2_vs_cre_DEseq_basic_counts_DESeq2.normalized.tsv.gz 1011.6 Kb (ftp)(http) TSV
GSE138981_endo_kansl3_vs_cre_DEseq_basic_DEresults.tsv.gz 1.5 Mb (ftp)(http) TSV
GSE138981_endo_kansl3_vs_cre_DEseq_basic_counts_DESeq2.normalized.tsv.gz 1008.1 Kb (ftp)(http) TSV
GSE138981_endo_mof_vs_cre_DEseq_basic_DEresults.tsv.gz 1.6 Mb (ftp)(http) TSV
GSE138981_endo_mof_vs_cre_DEseq_basic_counts_DESeq2.normalized.tsv.gz 1.1 Mb (ftp)(http) TSV
GSE138981_microglia_mof_vs_cre_DEseq_basic_DEresults.tsv.gz 1.4 Mb (ftp)(http) TSV
GSE138981_microglia_mof_vs_cre_DEseq_basic_counts_DESeq2.normalized.tsv.gz 713.3 Kb (ftp)(http) TSV
GSE138981_neural_kansl2_vs_cre_DEseq_basic_DEresults.tsv.gz 1.5 Mb (ftp)(http) TSV
GSE138981_neural_kansl2_vs_cre_DEseq_basic_counts_DESeq2.normalized.tsv.gz 818.1 Kb (ftp)(http) TSV
GSE138981_neural_kansl3_vs_cre_DEseq_basic_DEresults.tsv.gz 1.6 Mb (ftp)(http) TSV
GSE138981_neural_kansl3_vs_cre_DEseq_basic_counts_DESeq2.normalized.tsv.gz 852.3 Kb (ftp)(http) TSV
GSE138981_neural_mof_vs_cre_DEseq_basic_DEresults.tsv.gz 1.5 Mb (ftp)(http) TSV
GSE138981_neural_mof_vs_cre_DEseq_basic_counts_DESeq2.normalized.tsv.gz 807.9 Kb (ftp)(http) TSV
GSE138981_pericytes_kansl2_vs_cre_DEseq_basic_DEresults.tsv.gz 1.6 Mb (ftp)(http) TSV
GSE138981_pericytes_kansl2_vs_cre_DEseq_basic_counts_DESeq2.normalized.tsv.gz 868.1 Kb (ftp)(http) TSV
GSE138981_pericytes_kansl3_vs_cre_DEseq_basic_DEresults.tsv.gz 1.6 Mb (ftp)(http) TSV
GSE138981_pericytes_kansl3_vs_cre_DEseq_basic_counts_DESeq2.normalized.tsv.gz 1002.6 Kb (ftp)(http) TSV
GSE138981_pericytes_mof_vs_cre_DEseq_basic_DEresults.tsv.gz 1.6 Mb (ftp)(http) TSV
GSE138981_pericytes_mof_vs_cre_DEseq_basic_counts_DESeq2.normalized.tsv.gz 850.9 Kb (ftp)(http) TSV
GSE138981_whole_brain_geneCounts.txt.gz 549.3 Kb (ftp)(http) TXT
GSE138981_whole_brain_kansl2_differential_genes.txt.gz 1.6 Mb (ftp)(http) TXT
GSE138981_whole_brain_kansl3_differential_genes.txt.gz 1.6 Mb (ftp)(http) TXT
GSE138981_whole_brain_mof_differential_genes.txt.gz 1.6 Mb (ftp)(http) TXT
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Processed data are available on Series record

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