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Series GSE139169 Query DataSets for GSE139169
Status Public on Oct 22, 2019
Title RUNX2/CBFB modulates the response to MEK inhibitors through activation of receptor tyrosine kinases in KRAS mutant colorectal cancer
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Investigation of the transcriptional consequences of RUNX2 and CBFB loss in the presence and absence of the MEK inhibitor selumetinib in LoVo ERN1 knockout KRAS mutant colorectal cancer cells.
 
Overall design RNA-seq comparison of LoVo ERN1 KO, LoVo ERN1/RUNX2 double KO, and LoVo ERN1/CBFB double KO cells treated with 1 uM selumetinib or vehicle.
 
Contributor(s) Sustic T, Bosdriesz E, Lieftink C, Wessels LF, Bernards R
Citation(s) 31865182
Submission date Oct 21, 2019
Last update date Jan 02, 2020
Contact name Evert Bosdriesz
Organization name VU University Amsterdam
Department Computer Science
Lab Centre for Integrative Bioinformatics VU
Street address De Boelelaan 1111
City Amsterdam
ZIP/Postal code 1081 HV Amsterdam
Country Netherlands
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (6)
GSM4132441 5B vehicle control 3912_3_TS3_GTGAAAC
GSM4132442 5B Selumetinib 3912_4_TS4_ATCACGA
GSM4132443 5B RUNX2 vehicle control 3912_5_TS5_TTAGGCA
Relations
BioProject PRJNA578685
SRA SRP226449

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE139169_readcounts-lovo-b9.tsv.gz 1.2 Mb (ftp)(http) TSV
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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