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| Status |
Public on Jul 28, 2020 |
| Title |
Transcriptome analysis of dissected muscle tissue from whole-animal Drosophila melanogaster tumour models across a time course. |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Transcriptomic profiling along a time course of muscle wasting revealed a progressive deregulation of muscle structure and organisation. An array of molecular signatures were associated with this deregulation, including a perturbed ubiquitin-proteasome system, an increase in the unfolded protein response, and an increase in MAPK pathway signalling.
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| |
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| Overall design |
Pooled dissected body wall muscle tissue was transcriptionally profiled in quadruplicate across a time course of muscle wasting.
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| |
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| Contributor(s) |
Newton H, Hirabayashi S, Wang Y |
| Citation(s) |
32938923 |
| |
| Submission date |
Nov 05, 2019 |
| Last update date |
Dec 04, 2020 |
| Contact name |
LMS Bioinformatics Core |
| E-mail(s) |
bioinformatics@lms.mrc.ac.uk
|
| Organization name |
MRC London Institute of Medical Sciences
|
| Department |
Bioinformatics Core
|
| Street address |
Hammersmith Hospital Campus, Du Cane Road
|
| City |
London |
| ZIP/Postal code |
W12 0NN |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL17275 |
Illumina HiSeq 2500 (Drosophila melanogaster) |
|
| Samples (16)
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| This SubSeries is part of SuperSeries: |
| GSE139958 |
Systemic muscle wasting drives tumourigenesis |
|
| Relations |
| BioProject |
PRJNA587733 |
| SRA |
SRP228604 |
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