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Series GSE139967 Query DataSets for GSE139967
Status Public on Nov 06, 2019
Title Transcriptome profiling of liver derived from calcium channel ITPR2 KO mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Cellular senescence is induced by multiple stresses and results in a stable proliferation arrest accompanied by a pro-inflammatory secretome. Senescent cells accumulate during aging, promoting various age-related pathologies and thus limiting lifespan. The endoplasmic reticulum ITPR2 release channel and calcium fluxes from the ER to the mitochondria have been identified as drivers of cellular senescence in human cells. Here we show that Itpr2 knockout mice display improved aging such as increased lifespan, a better response to metabolic stress, less immunosenescence, as well as less liver steatosis and fibrosis. Cellular senescence, which is known to promote these alterations, is decreased in both Itpr2 KO mice and Itpr2 KO embryo-derived cells. Interestingly, ablation of ITPR2 in vivo and in vitro decreases the number of contacts between the mitochondria and the ER and forced contacts between these two organelles induce premature senescence in normal cells. These new findings shed light on the role of contacts and facilitated exchanges between the ER and the mitochondria through ITPR2 in regulating senescence and physiological aging.
Overall design Transcriptome analysis has been performed on liver tissue derived from 3 independent WT or Itpr2 KO mice
Contributor(s) Ziegler DV, Vindrieux D, Bernard D, Flaman J
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Submission date Nov 05, 2019
Last update date Nov 08, 2019
Contact name jean-michel flaman
Phone +33687477812
Organization name Inserm 1052
Department CRCL
Street address 28 rue Laennec
City Lyon
ZIP/Postal code 69373
Country France
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (6)
GSM4150627 Wild-type mouse liver replicate 1
GSM4150628 Wild-type mouse liver replicate 2
GSM4150629 Wild-type mouse liver replicate 3
BioProject PRJNA587751

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Supplementary file Size Download File type/resource
GSE139967_RAW.tar 12.7 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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