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Series GSE140729 Query DataSets for GSE140729
Status Public on Sep 03, 2020
Title Structure of LINC00511-siRNA-conjugated nanobubbles and improvement of cisplatin sensitivity on triple negative breast cancer
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary In the present study, we prepared a novel theranostic agent loaded with LINC00511-siRNA, which not only can serve as the siRNA delivery platform but also as the UCA for contrast enhanced ultrasound (CEUS). Combined with low-frequency ultrasound exposure, the novel theranostic agent achieves the controlled release of LINC00511-siRNA and facilitates the transfection of LINC00511-siRNA. Furthermore, in order to investigate how LINC00511 affects drug resistance of TNBC, we conducted the RNA-Seq to gain new insights into the mechanisms of drug sensitivity.
 
Overall design MDA-MB-231 cells and MDA-MB-231/CDDP cells were used for the research. The cells were transfected using the nanoparticles with the aid of low-frequency ultrasound(LFUS) exposure. Two groups of pre-transfection cells and two groups of post-transfection cells were analyzed using high-throughput RNA sequencing.
 
Contributor(s) Wu B, Yuan Y, Li E, Jing H, Cheng W
Citation(s) 32497336
Submission date Nov 20, 2019
Last update date Sep 03, 2020
Contact name Bolin Wu
Organization name Harbin Medical University Cancer Hospital
Street address No.150, Haping Road, Nangang District
City Harbin
State/province Heilongjiang Province
ZIP/Postal code 150081
Country China
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (4)
GSM4182605 A: pre-transfection MDA-MB-231 cells
GSM4182606 B: post-transfection MDA-MB-231 cells
GSM4182607 C: pre-transfection MDA-MB-231/CDDP
Relations
BioProject PRJNA590703
SRA SRP230792

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE140729_B_vs_A.DEG_KEGG_pathway_enrichment_result_ALL.txt.gz 35.9 Kb (ftp)(http) TXT
GSE140729_B_vs_A.GO_Enrichment_result_ALL.txt.gz 979.2 Kb (ftp)(http) TXT
GSE140729_C_vs_A.DEG_KEGG_pathway_enrichment_result_ALL.txt.gz 3.5 Kb (ftp)(http) TXT
GSE140729_C_vs_A.GO_Enrichment_result_ALL.txt.gz 57.3 Kb (ftp)(http) TXT
GSE140729_D_vs_C.DEG_KEGG_pathway_enrichment_result_ALL.txt.gz 32.0 Kb (ftp)(http) TXT
GSE140729_D_vs_C.GO_Enrichment_result_ALL.txt.gz 854.4 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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