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Series GSE141180 Query DataSets for GSE141180
Status Public on Sep 27, 2021
Title H3K27me3 maintains the transcription program during epigenetic reprogramming in the mouse germ line [ChIP-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We used Ultra-Low native ChIP to interrogate the H3K27me3 and H3K9me3 chromatin states in primordial germ cells before and after gonadal reprogramming. Our data demonstrate that repressive heterochromatin is remodelled during epigenetic reprogramming.
Overall design We mapped genome-wide distribution of H3K9me3 and H3K27me3 from E10.5 and E13.5 primordial germ cells using adapted ultra-low native ChIP (ULI-nChIP). This allowed us to investigate the chromatin dynamics during genome-wide DNA demethylation.
Contributor(s) Huang T, Hajkova P, Wang Y
Citation(s) 34880491
Submission date Nov 29, 2019
Last update date Jan 03, 2022
Contact name LMS Bioinformatics Core
Organization name MRC London Institute of Medical Sciences
Department Bioinformatics Core
Street address Hammersmith Hospital Campus, Du Cane Road
City London
ZIP/Postal code W12 0NN
Country United Kingdom
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (31)
GSM4196610 E10.5 H3K27me3 rep1
GSM4196611 E10.5 H3K27me3 input rep1
GSM4196612 E10.5 H3K9me3 rep1
This SubSeries is part of SuperSeries:
GSE141182 H3K27me3 maintains the transcription program during epigenetic reprogramming in the mouse germ line
BioProject PRJNA592545
SRA SRP234033

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SOFT formatted family file(s) SOFTHelp
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Supplementary file Size Download File type/resource
GSE141180_RAW.tar 3.6 Gb (http)(custom) TAR (of BROADPEAK, BW)
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Raw data are available in SRA
Processed data provided as supplementary file

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