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Series GSE141688 Query DataSets for GSE141688
Status Public on Jun 02, 2021
Title Inflammation drives alternative first exon usage of critical immune genes including Aim2 [RNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Macrophage cells are essential components of the innate immune system and contain toll-like receptors (TLRs) that intiate the immune response when pathogen-associated molecular pattern molecules (PAMPs) are recognized.
In this experiment, we stimulate TLR4 in bone marrow-derived macrophage cells with lipopolysaccharide (LPS) for 6 hours to simmulate inflammation and study the resulting differential splicing landscape and gene expression.
Overall design Unstimulated or LPS stimulated Primary Bone Marrow Derived Macrophages (BMDMs) from WT mice were collected and placed in Trizol. RNA was isolated and sequenced using Illumina.
Contributor(s) Carpenter S, Brooks A
Citation(s) 34047695
Submission date Dec 09, 2019
Last update date Sep 01, 2021
Contact name Sergio Covarrubias
Phone 2132710156
Organization name UCSC
Department MCD
Lab Carpenter
Street address Thimann Receiving/Department Carpenter Lab/Biomed 125, 1156 High St., Thimann Labs
City Santa Cruz
State/province CA
ZIP/Postal code 95064
Country USA
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (6)
GSM4211119 1_Ctl_Mse_BMDM [RNA-seq]
GSM4211120 2_Ctl_Mse_BMDM [RNA-seq]
GSM4211121 3_Ctl_Mse_BMDM [RNA-seq]
This SubSeries is part of SuperSeries:
GSE141754 Inflammation drives alternative first exon usage of critical immune genes including Aim2
BioProject PRJNA594369
SRA SRP235279

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SOFT formatted family file(s) SOFTHelp
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Supplementary file Size Download File type/resource
GSE141688_deseq_results.xlsx 2.3 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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