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Series GSE141924 Query DataSets for GSE141924
Status Public on Jun 01, 2020
Title Transcriptome analysis of brain endothelial cells from EC-specific Glut1 knock-out pups (P6) as compared to wild type controls
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary To explore the mechanisms through which GLUT1 controls EC function, we compared transcriptomic alterations induced by loss of GLUT1 by performing RNA sequencing analysis on freshly isolated ECs from P6 GLUT1EC-/- brains. At P6, 447 genes were differentially expressed between WT and GLUT1-/- ECs. Subsequent gene set enrichment analysis showed that within the most differentially expressed pathways, several ones were related to p53, as well as inflammatory related pathways.
 
Overall design Examination of transcriptomic differences in GLUT1EC-/- vs WT controls
 
Contributor(s) Moheb G, Koen V
Citation(s) 32404031
Submission date Dec 12, 2019
Last update date Aug 10, 2020
Contact name Katrien De Bock
E-mail(s) katrien-debock@ethz.ch
Organization name ETH Zurich
Department D-HEST
Lab Lab of Exercise and Health
Street address Schorenstrasse 16
City Schwerzenbach
State/province Z├╝rich
ZIP/Postal code 8603
Country Switzerland
 
Platforms (1)
GPL21103 Illumina HiSeq 4000 (Mus musculus)
Samples (8)
GSM4216369 cage_275887_pup1_KO
GSM4216370 cage_275887_pup2_KO
GSM4216371 cage_275887_pup3_KO
This SubSeries is part of SuperSeries:
GSE141926 Transcriptome analysis of brain endothelial cells from EC-specific Glut1 knock-out mice
Relations
BioProject PRJNA595178
SRA SRP237346

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE141924_RAW.tar 1000.0 Kb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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