|
| Status |
Public on Nov 17, 2020 |
| Title |
Inhibition of BRD4 Partially Rescues Dilated Cardiomyopathy and Cardiac Arrhythmias in Myocyte-Specific Lamin A/C Null Mice [ChIP-Seq] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Deletion of Lmna, encoding nuclear membrane protein LMNA, specifically in mouse cardiac myocytes activates BRD4 and leads to heart failure, arrhythmias, myocardial fibrosis, apoptosis, and premature death, which were partially rescued upon inhibition of BRD4.
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| |
|
| Overall design |
ChIP-seq for BRD4 from Cardiac myocytes from 4 control (WT) and 4 Myocyte-Specific Lamin A/C Null Mice (Myh6-cre:LmnaF/F)
|
| |
|
| Contributor(s) |
Auguste G, Matkovich SJ, Coarfa C, Robertson MJ, Czernuszewicz G, Lombardi R, Gurha P, Marian AJ |
| Citation(s) |
32484798 |
| |
| Submission date |
Dec 16, 2019 |
| Last update date |
Nov 17, 2020 |
| Contact name |
Ali J Marian |
| E-mail(s) |
Ali.J.Marian@uth.tmc.edu
|
| Phone |
713-500-2350
|
| Organization name |
UTHSC, Houston
|
| Department |
Centre for Cardiovascular Genetics
|
| Lab |
Marian Lab
|
| Street address |
6770 Bertner Ave DAC C900a
|
| City |
Houaton |
| State/province |
Texas |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL21493 |
Illumina HiSeq 3000 (Mus musculus) |
|
| Samples (16)
|
|
| This SubSeries is part of SuperSeries: |
| GSE142129 |
Inhibition of BRD4 Partially Rescues Dilated Cardiomyopathy and Cardiac Arrhythmias in Myocyte-Specific Lamin A/C Null Mice |
|
| Relations |
| BioProject |
PRJNA595952 |
| SRA |
SRP237790 |
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