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| Status |
Public on Jan 01, 2021 |
| Title |
Genome-wide RNA-seq from PARP1 and PRC2 double-depleted MDA-MB-231 cell lines |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: To identify downstream signaling pathways mediated by PARP1 and PRC2 in breast cancer
Methods: RNAs isolated from MDA-MB-231 cells depleting PARP1 and EZH2 (PARP1 KO shEZH2) and PARP1 and SUZ12 (PARP1 KO shSUZ12) were analyzed by using an Illumina Nextseq500
Conclusions: Our study represents the first transcriptomic profiles of effects of PARP1 and PRC2 double deficiency in breast cancer
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| Overall design |
mRNAs prepared from wild type, PARP1-EZH2 double-depleted and PARP1-SUZ12 double-depleted MDA-MB-231 cells were analyzed in duplicaters by Illumina Nextseq500.
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| |
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| Contributor(s) |
Yang A, Kim M, Kim S |
| Citation missing |
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| |
| Submission date |
Dec 30, 2019 |
| Last update date |
Jan 01, 2021 |
| Contact name |
Mi Young Kim |
| E-mail(s) |
miyoungkim@kaist.ac.kr
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| Organization name |
KAIST
|
| Street address |
Biological science
|
| City |
DaeJeon |
| ZIP/Postal code |
305-701 |
| Country |
South Korea |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA598225 |
| SRA |
SRP239117 |
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