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Status |
Public on Jan 30, 2023 |
Title |
DGAT1 is a bona fide oncogene stimulating cell growth and suppressing oxidative stress while enabling fatty acid accumulation |
Organism |
Danio rerio |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Forced over-expression of dgat1a using the minicoopR system increased the rate of tumour formation in tp53m214K/m214k; mitfa-/-; nras G12D. This was through increased TOR signalling and alterations in key metabolic pathways.
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Overall design |
Examination of the effect of dgat1a overexpression in NRAS driven Zebrafish Melanoma using the miniCoopR system.
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Contributor(s) |
Wilcock DJ, Hurlstone AF |
Citation missing |
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Submission date |
Jan 30, 2020 |
Last update date |
Jan 30, 2023 |
Contact name |
Adam Hurlstone |
E-mail(s) |
adam.hurlstone@manchester.ac.uk
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Organization name |
University of Manchester
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Street address |
Michael Smith Building
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City |
Manchester |
ZIP/Postal code |
M13 9PT |
Country |
United Kingdom |
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Platforms (1) |
GPL21741 |
Illumina HiSeq 4000 (Danio rerio) |
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Samples (8)
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Relations |
BioProject |
PRJNA604017 |
SRA |
SRP246169 |