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Series GSE144746 Query DataSets for GSE144746
Status Public on Nov 24, 2020
Title Typical western diet exacerbates dystrophic neurite pathology in APP/PS1 and APP/PS1/Tau mouse models by reducing the clustering of microglia around β-amyloid plaques 
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Here, we studied the interaction between dietary (TWD) and genetic factors (APPswe/PS1dE9 and tau P301L mutations) and their effect on memory, brain pathology, global gene expression and on insulin-Akt-GSK3β pathway in brain of mice with four different AD-linked genetic backgrounds: wild-type (AwTw), APPswe/PS1dE9 (A+Tw), P301Ltau (AwT+), and triple transgenic (A+T+).
Overall design The study comprised of 45 female mice, 12 wild-type (AwTw), 11 APP/PS1 transgenic (A+Tw), 12 tau P301L transgenic (AwT+) and 10 transgenic for both APP/PS1 and tau P301L (A+T+).
Contributor(s) Marttinen M, Hiltunen M
Citation(s) 33168021
Submission date Feb 04, 2020
Last update date Nov 24, 2020
Contact name Mikael Marttinen
Organization name University of Eastern Finland
Department Biomedicine
Street address Yliopistonranta 1E
City Kuopio
ZIP/Postal code 70210
Country Finland
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (45)
GSM4295005 PM239
GSM4295006 PM241
GSM4295007 PM242
BioProject PRJNA604773
SRA SRP247152

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE144746_VsdBatchCorrected_counts_prefiltering10.csv.gz 5.4 Mb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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