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Series GSE145044 Query DataSets for GSE145044
Status Public on Mar 23, 2020
Title RNA-Seq profiling of LAQ vs Control mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Illumina mRNA-Seq, 18-20 million single end reads/sample with Bioinformatics of LAQ vs Control mice
Laquinimod (LAQ) was initially known as an immunomodulatory agent and was used to treat multiple sclerosis and alleviate demyelination in the mouse models of different diseases. We assumed that it may modulates gene transcription to influence protein function in the mouse brain, based on the previous finding. We therefore performed RNAseq detection of gene expression from the oligodendrocyte-enriched corpus callosum of 3-month-old PLP-150Q mice that had been treated with 5 mg/kg LAQ for two months. The control group was the age-matched PLP-150Q mice treated with purified water.
 
Overall design Examination of gene expression in PLP-150Q mouse corpus callosum after LAQ treatment, using 4 LAQ treated and 4 control mice.
 
Contributor(s) Yin P, Li S, Tharp G
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Submission date Feb 10, 2020
Last update date Mar 23, 2020
Contact name Gregory K Tharp
E-mail(s) gktharp@emory.edu
Phone 404-727-7797
Organization name Yerkes National Primate Research Center
Department Developmental and Cognitive Neuroscience
Lab Genomics Core
Street address 954 Gatewood Dr
City Atlanta
State/province GA
ZIP/Postal code 30329-4208
Country USA
 
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (8)
GSM4305112 1_CONTROL
GSM4305113 2_CONTROL
GSM4305114 3_CONTROL
Relations
BioProject PRJNA605789
SRA SRP247976

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE145044_481_Yin_8RNASeq_DESeq2_NormCounts.txt.gz 1.2 Mb (ftp)(http) TXT
GSE145044_481_Yin_8RNASeq_RawCounts.txt.gz 446.8 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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