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Series GSE145067 Query DataSets for GSE145067
Status Public on Feb 10, 2020
Title SCA17 knock-in mice brain transcriptomes
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary To identify brain region specific proteins that contribute to brain region specific neurodegeneration, RNA sequencing was performed using cerebellum, striatum and prefrontal cortex tissues from 3-month-old SCA17 knock-in (KI) mice and wild-type (WT) littermates. We find 245 cerebellar specifically dysregulated genes (110 up-regulated genes and 145 down-regulated genes), 133 striatum specifically dysregulated genes (45 up-regulated genes and 88 down-regulated genes) and 17 prefrontal cortex specifically dysregulated genes (4 up-regulated genes and 13 down-regulated genes). Combined with other evidences, we demonstrate that cerebellum-enriched protein INPP5A contributes to selective neuropathology in mouse model of Spinocerebellar ataxias type 17
Overall design To compare RNA level of cerebellum, striatum and prefrontal cortex from 3-month old WT and KI mice of SCA-17 by RNA sequencing, each group consists three mice.
Contributor(s) Liu Q, Pan Y, Li S, Li X, Tharp G
Citation(s) 32107387
Submission date Feb 10, 2020
Last update date Mar 09, 2020
Contact name Gregory K Tharp
Phone 404-727-7797
Organization name Yerkes National Primate Research Center
Department Developmental and Cognitive Neuroscience
Lab Genomics Core
Street address 954 Gatewood Dr
City Atlanta
State/province GA
ZIP/Postal code 30329-4208
Country USA
Platforms (1)
GPL21493 Illumina HiSeq 3000 (Mus musculus)
Samples (19)
GSM4305666 1_C1_KI
GSM4305667 2_C2_KI
GSM4305668 3_C3_KI
BioProject PRJNA605839
SRA SRP248035

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Supplementary file Size Download File type/resource
GSE145067_556_Qiong_DESeq2_NormCounts.txt.gz 2.7 Mb (ftp)(http) TXT
GSE145067_556_Qiong_RawCounts.txt.gz 803.1 Kb (ftp)(http) TXT
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Processed data are available on Series record

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