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Series GSE145393 Query DataSets for GSE145393
Status Public on May 19, 2020
Title Skeletal muscle transcriptome profile in LLC mice model of cancer cachexia [miRNA-seq]
Organism Mus musculus
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary Cancer cachexia is a metabolic syndrome with alterations in gene expression profile that consequently lead to skeletal muscle wasting. Here, we used RNA sequencing to analyze the microRNA expression profile in the tibialis anterior muscles of the Lewis lung carcinoma (LLC) model of cancer cachexia.
 
Overall design Eight-week-old healthy C57BL/10 male mice were inoculated subcutaneously with a total of 1.5 x106 LLC cells (7.5 x 105 cells in 0.1 mL PBS, in each flank). Ten mice (control group) were injected with equal volumes of 1X PBS. LCC and control mice were studied after 22 days after LLC cells inoculation when the LLC group had developed overt cachexia.
Web link https://doi.org/10.3389/fgene.2020.00541
 
Contributor(s) Geysson F, Robson C
Citation(s) 32547603
Submission date Feb 17, 2020
Last update date Jun 22, 2020
Contact name Geysson Javier Fernandez Garcia
E-mail(s) fernandez.garcia@unesp.br
Organization name UNESP
Street address Departamento morfologia IBB UNESPRubiao Junior
City Botucatu
State/province Sao Paulo
ZIP/Postal code 18603191
Country Brazil
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (9)
GSM4317643 Control 1 [miRNA]
GSM4317644 Control 2 [miRNA]
GSM4317645 Control 3 [miRNA]
Relations
BioProject PRJNA607068
SRA SRP249710

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE145393_RAW.tar 70.0 Kb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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