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Series GSE146255 Query DataSets for GSE146255
Status Public on Feb 16, 2021
Title Transcriptome analysis of bisphenol A (BPA) treated Y79 human retinoblastoma cells
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Purpose: finding differential transcripts usage in environmentally harzardous chemical, bisphenol A (BPA) in human retinal cells
Methods: transcriptome analysis by the RNA-seq via mRNA pull-down
Results: We found that BPA increases cellular toxicity by the increasing of early apoptotic pathway in Y79 cells. Also, over thounds of retained intron events were detected from the RNA-seq analysis.
Conclusions: Bisphenol A (BPA) increases early cytotoxic effects in Y79 cells through the early apoptotic pathway and changes the context of trascript through the splicing regulation mechanisms.
 
Overall design Y79 cells were treated with various concentration of bisphenol A and all experiments were duplicated.
 
Contributor(s) Kim J
Citation https://doi.org/10.3390/genes12020264
Submission date Mar 03, 2020
Last update date Feb 16, 2021
Contact name Jung-Woong Kim
E-mail(s) jungkim@cau.ac.kr
Organization name Chung-Ang University
Department Life Science
Lab Genome Dynamics Lab
Street address 84 Heuksuk-ro Dongjak-ku
City Seoul
ZIP/Postal code 06974
Country South Korea
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (4)
GSM4369036 DMSO rep1
GSM4369037 DMSO rep2
GSM4369038 BPA rep1
Relations
BioProject PRJNA609898
SRA SRP251351

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE146255_normalized_counts_FPKM_.txt.gz 2.4 Mb (ftp)(http) TXT
GSE146255_raw_counts.txt.gz 894.8 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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